Renal renin and hemodynamic responses to selective renal artery catheterization and angiography

Richard W Katzberg, T. W. Morris, F. A. Burgener, D. E. Kamm, H. W. Fischer

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


Selective renal artery catheterization and renal angiography are commonly performed diagnostic procedures; ho wever, the effects of these procedures on renal blood flow (RBF) and renin release have only been partially described. A biphasic RBF response has been well documented during selective angiography in dogs. The renal autoregulatory mechanisms governing the responses are uncertain. The renin-angiotensin system and the major parameters of contrast media, hypertonicity and viscosity, have been suggested as important factors. In the canine model, the authors examined the acute changes in renal venous renin activity along with the renal hemodynamic effects of hypertonicity and viscosity. The authors' results do not support a primary effect mediated by the renin-angiotensin system. Hypertonicity and the contrast medium per se are significant in active and passive autoregulatory responses at the smooth muscle cellular level.

Original languageEnglish (US)
Pages (from-to)381-388
Number of pages8
JournalInvestigative Radiology
Issue number5
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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