Renal Medullary Amyloidosis in Dorcas Gazelles

B. A. Rideout, R. J. Montali, R. S. Wallace, M. Bush, Lyndsay Phillips, T. T. Antonovych, S. G. Sabnis

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Between January 1976 and September 1987 renal medullary amyloidosis (RMA) was diagnosed in 17 Dorcas gazelles; the necropsy prevalence rate was 17/32 (53%). The most severe amyloid deposits were in the renal medulla; glomeruli were spared. Renal cortical lesions of interstitial fibrosis and tubular atrophy and dilatation significantly correlated with RMA (P < 0.01) and were considered to be secondary changes. There were varying degrees of lymphoplasmacytic inflammation and tubular cast formation which did not significantly correlate with RMA. Amyloid was confirmed histochemically and by electron microscopy and was identified as AA type by the permanganate method. Progressive renal failure was the cause of death or necessitated euthanasia in 7/17 (41%) gazelles. RMA in Dorcas gazelles does not appear to be familial. A high prevalence of chronic or recurring Actinomyces (Corynebacterium) pyogenes infections may be an important factor.

Original languageEnglish (US)
Pages (from-to)129-135
Number of pages7
JournalVeterinary Pathology
Volume26
Issue number2
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)

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    Rideout, B. A., Montali, R. J., Wallace, R. S., Bush, M., Phillips, L., Antonovych, T. T., & Sabnis, S. G. (1989). Renal Medullary Amyloidosis in Dorcas Gazelles. Veterinary Pathology, 26(2), 129-135. https://doi.org/10.1177/030098588902600205