Renal cell carcinoma metastases to the pancreas: Value of arterial phase imaging at MDCT

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The pancreas is an increasingly recognized site of renal cell carcinoma metastases. It is important to determine the optimal MDCT protocol to best detect RCC metastases to the pancreas. Purpose: To compare the rate of detection of renal cell carcinoma metastases to the pancreas between arterial and portal venous phase MDCT. Material and Methods: A retrospective review of CTs of the abdomen yielded six patients with metastatic RCC to the pancreas. Five of six patients had pathologically proven clear cell RCC. Two blinded reviewers independently reported the number of pancreatic lesions seen in arterial and venous phases. Each lesion was graded as definite or possible. The number of lesions was determined by consensus review of both phases. Attenuation values were obtained for metastatic lesions and adjacent normal pancreas in both phases. Results: There were a total of 24 metastatic lesions to the pancreas. Reviewer 1 identified 20/24 (83.3%) lesions on the arterial phase images and 13/24 (54.2%) lesions on the venous phase. Seventeen of 20 (85.0%) arterial lesions were deemed definite and 9/13 (69.2%) venous lesions were definite. Reviewer 2 identified 19/24 (79.2%) lesions on the arterial phase and 14/24 (58.3%) on the venous phase. Seventeen of 19 (89.5%) arterial lesions were definite and 7/14 (50%) venous lesions were definite. Mean attenuation differential between lesion and pancreas was 114 HU and 39 HU for arterial and venous phases, respectively (P<0.0001). Conclusion: Detection of RCC metastases to the pancreas at MDCT is improved using arterial phase imaging compared to portal venous phase imaging.

Original languageEnglish (US)
Pages (from-to)349-354
Number of pages6
JournalActa Radiologica
Volume54
Issue number3
DOIs
StatePublished - 2013

Fingerprint

Renal Cell Carcinoma
Pancreas
Neoplasm Metastasis
Abdomen

Keywords

  • Arterial phase
  • MDCT
  • Metastasis
  • Pancreas
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Medicine(all)

Cite this

Renal cell carcinoma metastases to the pancreas : Value of arterial phase imaging at MDCT. / Corwin, Michael T; Lamba, Ramit; Wilson, Machelle; McGahan, John P.

In: Acta Radiologica, Vol. 54, No. 3, 2013, p. 349-354.

Research output: Contribution to journalArticle

@article{213da761abbd409f98aecc80ced9254a,
title = "Renal cell carcinoma metastases to the pancreas: Value of arterial phase imaging at MDCT",
abstract = "Background: The pancreas is an increasingly recognized site of renal cell carcinoma metastases. It is important to determine the optimal MDCT protocol to best detect RCC metastases to the pancreas. Purpose: To compare the rate of detection of renal cell carcinoma metastases to the pancreas between arterial and portal venous phase MDCT. Material and Methods: A retrospective review of CTs of the abdomen yielded six patients with metastatic RCC to the pancreas. Five of six patients had pathologically proven clear cell RCC. Two blinded reviewers independently reported the number of pancreatic lesions seen in arterial and venous phases. Each lesion was graded as definite or possible. The number of lesions was determined by consensus review of both phases. Attenuation values were obtained for metastatic lesions and adjacent normal pancreas in both phases. Results: There were a total of 24 metastatic lesions to the pancreas. Reviewer 1 identified 20/24 (83.3{\%}) lesions on the arterial phase images and 13/24 (54.2{\%}) lesions on the venous phase. Seventeen of 20 (85.0{\%}) arterial lesions were deemed definite and 9/13 (69.2{\%}) venous lesions were definite. Reviewer 2 identified 19/24 (79.2{\%}) lesions on the arterial phase and 14/24 (58.3{\%}) on the venous phase. Seventeen of 19 (89.5{\%}) arterial lesions were definite and 7/14 (50{\%}) venous lesions were definite. Mean attenuation differential between lesion and pancreas was 114 HU and 39 HU for arterial and venous phases, respectively (P<0.0001). Conclusion: Detection of RCC metastases to the pancreas at MDCT is improved using arterial phase imaging compared to portal venous phase imaging.",
keywords = "Arterial phase, MDCT, Metastasis, Pancreas, Renal cell carcinoma",
author = "Corwin, {Michael T} and Ramit Lamba and Machelle Wilson and McGahan, {John P}",
year = "2013",
doi = "10.1258/ar.2012.120693",
language = "English (US)",
volume = "54",
pages = "349--354",
journal = "Acta Radiologica",
issn = "0284-1851",
publisher = "SAGE Publications Ltd",
number = "3",

}

TY - JOUR

T1 - Renal cell carcinoma metastases to the pancreas

T2 - Value of arterial phase imaging at MDCT

AU - Corwin, Michael T

AU - Lamba, Ramit

AU - Wilson, Machelle

AU - McGahan, John P

PY - 2013

Y1 - 2013

N2 - Background: The pancreas is an increasingly recognized site of renal cell carcinoma metastases. It is important to determine the optimal MDCT protocol to best detect RCC metastases to the pancreas. Purpose: To compare the rate of detection of renal cell carcinoma metastases to the pancreas between arterial and portal venous phase MDCT. Material and Methods: A retrospective review of CTs of the abdomen yielded six patients with metastatic RCC to the pancreas. Five of six patients had pathologically proven clear cell RCC. Two blinded reviewers independently reported the number of pancreatic lesions seen in arterial and venous phases. Each lesion was graded as definite or possible. The number of lesions was determined by consensus review of both phases. Attenuation values were obtained for metastatic lesions and adjacent normal pancreas in both phases. Results: There were a total of 24 metastatic lesions to the pancreas. Reviewer 1 identified 20/24 (83.3%) lesions on the arterial phase images and 13/24 (54.2%) lesions on the venous phase. Seventeen of 20 (85.0%) arterial lesions were deemed definite and 9/13 (69.2%) venous lesions were definite. Reviewer 2 identified 19/24 (79.2%) lesions on the arterial phase and 14/24 (58.3%) on the venous phase. Seventeen of 19 (89.5%) arterial lesions were definite and 7/14 (50%) venous lesions were definite. Mean attenuation differential between lesion and pancreas was 114 HU and 39 HU for arterial and venous phases, respectively (P<0.0001). Conclusion: Detection of RCC metastases to the pancreas at MDCT is improved using arterial phase imaging compared to portal venous phase imaging.

AB - Background: The pancreas is an increasingly recognized site of renal cell carcinoma metastases. It is important to determine the optimal MDCT protocol to best detect RCC metastases to the pancreas. Purpose: To compare the rate of detection of renal cell carcinoma metastases to the pancreas between arterial and portal venous phase MDCT. Material and Methods: A retrospective review of CTs of the abdomen yielded six patients with metastatic RCC to the pancreas. Five of six patients had pathologically proven clear cell RCC. Two blinded reviewers independently reported the number of pancreatic lesions seen in arterial and venous phases. Each lesion was graded as definite or possible. The number of lesions was determined by consensus review of both phases. Attenuation values were obtained for metastatic lesions and adjacent normal pancreas in both phases. Results: There were a total of 24 metastatic lesions to the pancreas. Reviewer 1 identified 20/24 (83.3%) lesions on the arterial phase images and 13/24 (54.2%) lesions on the venous phase. Seventeen of 20 (85.0%) arterial lesions were deemed definite and 9/13 (69.2%) venous lesions were definite. Reviewer 2 identified 19/24 (79.2%) lesions on the arterial phase and 14/24 (58.3%) on the venous phase. Seventeen of 19 (89.5%) arterial lesions were definite and 7/14 (50%) venous lesions were definite. Mean attenuation differential between lesion and pancreas was 114 HU and 39 HU for arterial and venous phases, respectively (P<0.0001). Conclusion: Detection of RCC metastases to the pancreas at MDCT is improved using arterial phase imaging compared to portal venous phase imaging.

KW - Arterial phase

KW - MDCT

KW - Metastasis

KW - Pancreas

KW - Renal cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=84877929163&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84877929163&partnerID=8YFLogxK

U2 - 10.1258/ar.2012.120693

DO - 10.1258/ar.2012.120693

M3 - Article

C2 - 23325783

AN - SCOPUS:84877929163

VL - 54

SP - 349

EP - 354

JO - Acta Radiologica

JF - Acta Radiologica

SN - 0284-1851

IS - 3

ER -