Removal of dabigatran by hemodialysis

Don N. Chang, William E. Dager, Andrew I Chin

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Dabigatran is a newly available oral direct thrombin inhibitor approved for anticoagulation therapy to prevent strokes in patients with nonvalvular atrial fibrillation. Unlike warfarin, dabigatran's observed therapeutic window and minimal drug-to-drug interaction suggest that invasive laboratory testing and dose adjustment is not necessary. In circumstances of excessive anticoagulation, such as overdoses, decreased kidney function, or instances of significant bleeding, reversing dabigatran's effects may be necessary. Unlike warfarin, no rapid-acting antidote to reverse the effects of dabigatran is known. However, hemodialysis has been suggested as a method of removing dabigatran and thereby reducing its anticoagulant effect. We describe a case in which hemodialysis was used in an attempt to remove dabigatran in a patient with excessive anticoagulation from dabigatran and severe intracranial hemorrhage. Serial dabigatran levels suggested that hemodialysis removed the drug. However, given the large volume of distribution of dabigatran in the terminal phase of elimination, a rebound in drug level was noted. We suggest that a longer duration of therapy or more continuous modality of hemodialysis may be needed in conjunction with the initial hemodialysis treatment of dabigatran coagulopathy.

Original languageEnglish (US)
Pages (from-to)487-489
Number of pages3
JournalAmerican Journal of Kidney Diseases
Volume61
Issue number3
DOIs
StatePublished - Mar 2013

Fingerprint

Renal Dialysis
Warfarin
Dabigatran
Pharmaceutical Preparations
Antidotes
Antithrombins
Intracranial Hemorrhages
Therapeutics
Drug Interactions
Anticoagulants
Atrial Fibrillation
Stroke
Hemorrhage
Kidney

Keywords

  • Dabigatran
  • hemodialysis
  • Pradaxa

ASJC Scopus subject areas

  • Nephrology

Cite this

Removal of dabigatran by hemodialysis. / Chang, Don N.; Dager, William E.; Chin, Andrew I.

In: American Journal of Kidney Diseases, Vol. 61, No. 3, 03.2013, p. 487-489.

Research output: Contribution to journalArticle

Chang, Don N. ; Dager, William E. ; Chin, Andrew I. / Removal of dabigatran by hemodialysis. In: American Journal of Kidney Diseases. 2013 ; Vol. 61, No. 3. pp. 487-489.
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