Remission of membranoproliferative glomerulonephritis type I with the use of tacrolimus

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Membranoproliferative glomerulonephritis, albeit uncommon, is associated with considerable morbidity and mortality in children. Corticosteroids are the mainstay of therapy for severe disease, although data supporting their use are limited. We report our experience in treating two children with nephrotic-nephritic syndrome from idiopathic membranoproliferative glomerulonephritis. Both children experienced a suboptimal response to prolonged courses of steroids and were started on tacrolimus as a steroid-sparing agent. Rapid and complete remission was achieved in both children after initiation of tacrolimus. The purpose of our report is to increase awareness of health care professionals to the potential benefits of this agent in inducing remission in children with severe membranoproliferative glomerulonephritis.

Original languageEnglish (US)
Pages (from-to)1787-1791
Number of pages5
JournalPediatric Nephrology
Volume22
Issue number10
DOIs
StatePublished - Oct 2007

Fingerprint

Membranoproliferative Glomerulonephritis
Tacrolimus
Steroids
Child Mortality
Adrenal Cortex Hormones
Morbidity
Delivery of Health Care
Kidney

Keywords

  • MPGN
  • Nephrotic syndrome
  • Pediatric
  • Remission

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Remission of membranoproliferative glomerulonephritis type I with the use of tacrolimus. / Haddad, Maha; Lau, Keith; Butani, Lavjay.

In: Pediatric Nephrology, Vol. 22, No. 10, 10.2007, p. 1787-1791.

Research output: Contribution to journalArticle

@article{f20042473f0740f8a83fec57dbd52541,
title = "Remission of membranoproliferative glomerulonephritis type I with the use of tacrolimus",
abstract = "Membranoproliferative glomerulonephritis, albeit uncommon, is associated with considerable morbidity and mortality in children. Corticosteroids are the mainstay of therapy for severe disease, although data supporting their use are limited. We report our experience in treating two children with nephrotic-nephritic syndrome from idiopathic membranoproliferative glomerulonephritis. Both children experienced a suboptimal response to prolonged courses of steroids and were started on tacrolimus as a steroid-sparing agent. Rapid and complete remission was achieved in both children after initiation of tacrolimus. The purpose of our report is to increase awareness of health care professionals to the potential benefits of this agent in inducing remission in children with severe membranoproliferative glomerulonephritis.",
keywords = "MPGN, Nephrotic syndrome, Pediatric, Remission",
author = "Maha Haddad and Keith Lau and Lavjay Butani",
year = "2007",
month = "10",
doi = "10.1007/s00467-007-0523-1",
language = "English (US)",
volume = "22",
pages = "1787--1791",
journal = "Pediatric Nephrology",
issn = "0931-041X",
publisher = "Springer Verlag",
number = "10",

}

TY - JOUR

T1 - Remission of membranoproliferative glomerulonephritis type I with the use of tacrolimus

AU - Haddad, Maha

AU - Lau, Keith

AU - Butani, Lavjay

PY - 2007/10

Y1 - 2007/10

N2 - Membranoproliferative glomerulonephritis, albeit uncommon, is associated with considerable morbidity and mortality in children. Corticosteroids are the mainstay of therapy for severe disease, although data supporting their use are limited. We report our experience in treating two children with nephrotic-nephritic syndrome from idiopathic membranoproliferative glomerulonephritis. Both children experienced a suboptimal response to prolonged courses of steroids and were started on tacrolimus as a steroid-sparing agent. Rapid and complete remission was achieved in both children after initiation of tacrolimus. The purpose of our report is to increase awareness of health care professionals to the potential benefits of this agent in inducing remission in children with severe membranoproliferative glomerulonephritis.

AB - Membranoproliferative glomerulonephritis, albeit uncommon, is associated with considerable morbidity and mortality in children. Corticosteroids are the mainstay of therapy for severe disease, although data supporting their use are limited. We report our experience in treating two children with nephrotic-nephritic syndrome from idiopathic membranoproliferative glomerulonephritis. Both children experienced a suboptimal response to prolonged courses of steroids and were started on tacrolimus as a steroid-sparing agent. Rapid and complete remission was achieved in both children after initiation of tacrolimus. The purpose of our report is to increase awareness of health care professionals to the potential benefits of this agent in inducing remission in children with severe membranoproliferative glomerulonephritis.

KW - MPGN

KW - Nephrotic syndrome

KW - Pediatric

KW - Remission

UR - http://www.scopus.com/inward/record.url?scp=34548312531&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548312531&partnerID=8YFLogxK

U2 - 10.1007/s00467-007-0523-1

DO - 10.1007/s00467-007-0523-1

M3 - Article

VL - 22

SP - 1787

EP - 1791

JO - Pediatric Nephrology

JF - Pediatric Nephrology

SN - 0931-041X

IS - 10

ER -