REM sleep behavior disorder and neuropathology in Parkinson's disease

Ronald B. Postuma, Charles H. Adler, Brittany Dugger, Joseph G. Hentz, Holly A. Shill, Erika Driver-Dunckley, Marwan N. Sabbagh, Sandra A. Jacobson, Christine M. Belden, Lucia I. Sue, Geidy Serrano, Thomas G. Beach

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Introduction: Rapid eye movement (REM) sleep behavior disorder (RBD) in Parkinson's disease (PD) is associated with differences in clinical phenotype, including dementia, autonomic loss, and gait dysfunction. The pathological basis for this remains unclear. Methods: Parkinson's disease subjects in a longitudinal clinicopathologic study were screened for probable RBD with the Mayo Sleep Questionnaire. After death, semiquantitative analyses were conducted for synuclein, amyloid, neurofibrillary tangles, and cerebrovascular lesions. Results: Forty cases had probable RBD (PD+RBD), and 41 did not (PD-RBD). Despite similar age at death (∼80 y) and disease duration (∼14.5 y), PD+RBD had increased synuclein deposition in all regions examined, with nine of 10 regions significantly different. The Lewy body 10-region total score (scale = 0-40) was 29.5 in PD+RBD versus 24.5 in PD-RBD (Cohen-d effect size = 0.79, P = 0.002). Cerebrovascular lesion burden was slightly higher in PD-RBD. Conclusions: Although overlap occurs between groups, PD patients with probable RBD may have greater density and range of synuclein pathology on autopsy.

Original languageEnglish (US)
Pages (from-to)1413-1417
Number of pages5
JournalMovement Disorders
Volume30
Issue number10
DOIs
StatePublished - Sep 1 2015
Externally publishedYes

Fingerprint

REM Sleep Behavior Disorder
Parkinson Disease
Synucleins
Neuropathology
Lewy Bodies
Body Regions
Neurofibrillary Tangles
Gait
Amyloid
Longitudinal Studies
Dementia
Autopsy
Sleep

Keywords

  • Diagnosis
  • Parkinson's disease
  • Pathology
  • REM sleep behavior disorder

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Postuma, R. B., Adler, C. H., Dugger, B., Hentz, J. G., Shill, H. A., Driver-Dunckley, E., ... Beach, T. G. (2015). REM sleep behavior disorder and neuropathology in Parkinson's disease. Movement Disorders, 30(10), 1413-1417. https://doi.org/10.1002/mds.26347

REM sleep behavior disorder and neuropathology in Parkinson's disease. / Postuma, Ronald B.; Adler, Charles H.; Dugger, Brittany; Hentz, Joseph G.; Shill, Holly A.; Driver-Dunckley, Erika; Sabbagh, Marwan N.; Jacobson, Sandra A.; Belden, Christine M.; Sue, Lucia I.; Serrano, Geidy; Beach, Thomas G.

In: Movement Disorders, Vol. 30, No. 10, 01.09.2015, p. 1413-1417.

Research output: Contribution to journalArticle

Postuma, RB, Adler, CH, Dugger, B, Hentz, JG, Shill, HA, Driver-Dunckley, E, Sabbagh, MN, Jacobson, SA, Belden, CM, Sue, LI, Serrano, G & Beach, TG 2015, 'REM sleep behavior disorder and neuropathology in Parkinson's disease', Movement Disorders, vol. 30, no. 10, pp. 1413-1417. https://doi.org/10.1002/mds.26347
Postuma RB, Adler CH, Dugger B, Hentz JG, Shill HA, Driver-Dunckley E et al. REM sleep behavior disorder and neuropathology in Parkinson's disease. Movement Disorders. 2015 Sep 1;30(10):1413-1417. https://doi.org/10.1002/mds.26347
Postuma, Ronald B. ; Adler, Charles H. ; Dugger, Brittany ; Hentz, Joseph G. ; Shill, Holly A. ; Driver-Dunckley, Erika ; Sabbagh, Marwan N. ; Jacobson, Sandra A. ; Belden, Christine M. ; Sue, Lucia I. ; Serrano, Geidy ; Beach, Thomas G. / REM sleep behavior disorder and neuropathology in Parkinson's disease. In: Movement Disorders. 2015 ; Vol. 30, No. 10. pp. 1413-1417.
@article{d5a53686621948c194bb7410bc4f1de5,
title = "REM sleep behavior disorder and neuropathology in Parkinson's disease",
abstract = "Introduction: Rapid eye movement (REM) sleep behavior disorder (RBD) in Parkinson's disease (PD) is associated with differences in clinical phenotype, including dementia, autonomic loss, and gait dysfunction. The pathological basis for this remains unclear. Methods: Parkinson's disease subjects in a longitudinal clinicopathologic study were screened for probable RBD with the Mayo Sleep Questionnaire. After death, semiquantitative analyses were conducted for synuclein, amyloid, neurofibrillary tangles, and cerebrovascular lesions. Results: Forty cases had probable RBD (PD+RBD), and 41 did not (PD-RBD). Despite similar age at death (∼80 y) and disease duration (∼14.5 y), PD+RBD had increased synuclein deposition in all regions examined, with nine of 10 regions significantly different. The Lewy body 10-region total score (scale = 0-40) was 29.5 in PD+RBD versus 24.5 in PD-RBD (Cohen-d effect size = 0.79, P = 0.002). Cerebrovascular lesion burden was slightly higher in PD-RBD. Conclusions: Although overlap occurs between groups, PD patients with probable RBD may have greater density and range of synuclein pathology on autopsy.",
keywords = "Diagnosis, Parkinson's disease, Pathology, REM sleep behavior disorder",
author = "Postuma, {Ronald B.} and Adler, {Charles H.} and Brittany Dugger and Hentz, {Joseph G.} and Shill, {Holly A.} and Erika Driver-Dunckley and Sabbagh, {Marwan N.} and Jacobson, {Sandra A.} and Belden, {Christine M.} and Sue, {Lucia I.} and Geidy Serrano and Beach, {Thomas G.}",
year = "2015",
month = "9",
day = "1",
doi = "10.1002/mds.26347",
language = "English (US)",
volume = "30",
pages = "1413--1417",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "10",

}

TY - JOUR

T1 - REM sleep behavior disorder and neuropathology in Parkinson's disease

AU - Postuma, Ronald B.

AU - Adler, Charles H.

AU - Dugger, Brittany

AU - Hentz, Joseph G.

AU - Shill, Holly A.

AU - Driver-Dunckley, Erika

AU - Sabbagh, Marwan N.

AU - Jacobson, Sandra A.

AU - Belden, Christine M.

AU - Sue, Lucia I.

AU - Serrano, Geidy

AU - Beach, Thomas G.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Introduction: Rapid eye movement (REM) sleep behavior disorder (RBD) in Parkinson's disease (PD) is associated with differences in clinical phenotype, including dementia, autonomic loss, and gait dysfunction. The pathological basis for this remains unclear. Methods: Parkinson's disease subjects in a longitudinal clinicopathologic study were screened for probable RBD with the Mayo Sleep Questionnaire. After death, semiquantitative analyses were conducted for synuclein, amyloid, neurofibrillary tangles, and cerebrovascular lesions. Results: Forty cases had probable RBD (PD+RBD), and 41 did not (PD-RBD). Despite similar age at death (∼80 y) and disease duration (∼14.5 y), PD+RBD had increased synuclein deposition in all regions examined, with nine of 10 regions significantly different. The Lewy body 10-region total score (scale = 0-40) was 29.5 in PD+RBD versus 24.5 in PD-RBD (Cohen-d effect size = 0.79, P = 0.002). Cerebrovascular lesion burden was slightly higher in PD-RBD. Conclusions: Although overlap occurs between groups, PD patients with probable RBD may have greater density and range of synuclein pathology on autopsy.

AB - Introduction: Rapid eye movement (REM) sleep behavior disorder (RBD) in Parkinson's disease (PD) is associated with differences in clinical phenotype, including dementia, autonomic loss, and gait dysfunction. The pathological basis for this remains unclear. Methods: Parkinson's disease subjects in a longitudinal clinicopathologic study were screened for probable RBD with the Mayo Sleep Questionnaire. After death, semiquantitative analyses were conducted for synuclein, amyloid, neurofibrillary tangles, and cerebrovascular lesions. Results: Forty cases had probable RBD (PD+RBD), and 41 did not (PD-RBD). Despite similar age at death (∼80 y) and disease duration (∼14.5 y), PD+RBD had increased synuclein deposition in all regions examined, with nine of 10 regions significantly different. The Lewy body 10-region total score (scale = 0-40) was 29.5 in PD+RBD versus 24.5 in PD-RBD (Cohen-d effect size = 0.79, P = 0.002). Cerebrovascular lesion burden was slightly higher in PD-RBD. Conclusions: Although overlap occurs between groups, PD patients with probable RBD may have greater density and range of synuclein pathology on autopsy.

KW - Diagnosis

KW - Parkinson's disease

KW - Pathology

KW - REM sleep behavior disorder

UR - http://www.scopus.com/inward/record.url?scp=84941172960&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941172960&partnerID=8YFLogxK

U2 - 10.1002/mds.26347

DO - 10.1002/mds.26347

M3 - Article

C2 - 26265105

AN - SCOPUS:84941172960

VL - 30

SP - 1413

EP - 1417

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 10

ER -