Abstract
Study Design Prospective study. Objective Because single-level disk arthroplasty or arthrodesis in the lower subaxial spine improves headaches after surgery, we studied whether this effect may be better appreciated after two-level arthroplasty. Methods We performed an independent post hoc analysis of two concurrent prospective randomized investigational device exemption trials for cervical spondylosis, one for single-level treatment and the other for two adjacent-level treatments. Results For the one-level study, baseline mean headache scores significantly improved at 60 months for both the cervical disk arthroplasty (CDA) and anterior cervical diskectomy and fusion (ACDF) groups (p < 0.0001). However, mean improvement in headache scores was not statistically different between the investigational and control groups from 6 months through 60 months. For the two-level study, baseline mean headache scores significantly improved at 60 months for both the CDA and ACDF groups (p < 0.0001). The CDA group demonstrated greater improvement from baseline at all points; this difference was statistically significant at 6, 12, 24, 36, and 48 months but not at 18 and 60 months. Conclusion Both CDA and ACDF at either one or two levels are associated with sustained headache relief from baseline. Patients undergoing two-level arthroplasty had significantly greater improvement in headache at all points except for at 18 and 60 months. This difference in improvement was not observed in patients undergoing single-level arthroplasty. The mechanism of greater headache relief after two-level arthroplasty remains unclear.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 563-570 |
| Number of pages | 8 |
| Journal | Global Spine Journal |
| Volume | 6 |
| Issue number | 6 |
| DOIs | |
| State | Published - Sep 1 2016 |
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Keywords
- cervical disk arthroplasty
- cervical fusion
- cervicogenic headache
- headache
ASJC Scopus subject areas
- Surgery
- Orthopedics and Sports Medicine
- Clinical Neurology
Cite this
Relief of Cervicogenic Headaches after Single-Level and Multilevel Anterior Cervical Diskectomy : A 5-Year Post Hoc Analysis. / Liu, Jonathan J.; Cadena, Gilbert; Panchal, Ripul R.; Schrot, Rudolph J.; Kim, Kee D.
In: Global Spine Journal, Vol. 6, No. 6, 01.09.2016, p. 563-570.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relief of Cervicogenic Headaches after Single-Level and Multilevel Anterior Cervical Diskectomy
T2 - A 5-Year Post Hoc Analysis
AU - Liu, Jonathan J.
AU - Cadena, Gilbert
AU - Panchal, Ripul R.
AU - Schrot, Rudolph J.
AU - Kim, Kee D
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Study Design Prospective study. Objective Because single-level disk arthroplasty or arthrodesis in the lower subaxial spine improves headaches after surgery, we studied whether this effect may be better appreciated after two-level arthroplasty. Methods We performed an independent post hoc analysis of two concurrent prospective randomized investigational device exemption trials for cervical spondylosis, one for single-level treatment and the other for two adjacent-level treatments. Results For the one-level study, baseline mean headache scores significantly improved at 60 months for both the cervical disk arthroplasty (CDA) and anterior cervical diskectomy and fusion (ACDF) groups (p < 0.0001). However, mean improvement in headache scores was not statistically different between the investigational and control groups from 6 months through 60 months. For the two-level study, baseline mean headache scores significantly improved at 60 months for both the CDA and ACDF groups (p < 0.0001). The CDA group demonstrated greater improvement from baseline at all points; this difference was statistically significant at 6, 12, 24, 36, and 48 months but not at 18 and 60 months. Conclusion Both CDA and ACDF at either one or two levels are associated with sustained headache relief from baseline. Patients undergoing two-level arthroplasty had significantly greater improvement in headache at all points except for at 18 and 60 months. This difference in improvement was not observed in patients undergoing single-level arthroplasty. The mechanism of greater headache relief after two-level arthroplasty remains unclear.
AB - Study Design Prospective study. Objective Because single-level disk arthroplasty or arthrodesis in the lower subaxial spine improves headaches after surgery, we studied whether this effect may be better appreciated after two-level arthroplasty. Methods We performed an independent post hoc analysis of two concurrent prospective randomized investigational device exemption trials for cervical spondylosis, one for single-level treatment and the other for two adjacent-level treatments. Results For the one-level study, baseline mean headache scores significantly improved at 60 months for both the cervical disk arthroplasty (CDA) and anterior cervical diskectomy and fusion (ACDF) groups (p < 0.0001). However, mean improvement in headache scores was not statistically different between the investigational and control groups from 6 months through 60 months. For the two-level study, baseline mean headache scores significantly improved at 60 months for both the CDA and ACDF groups (p < 0.0001). The CDA group demonstrated greater improvement from baseline at all points; this difference was statistically significant at 6, 12, 24, 36, and 48 months but not at 18 and 60 months. Conclusion Both CDA and ACDF at either one or two levels are associated with sustained headache relief from baseline. Patients undergoing two-level arthroplasty had significantly greater improvement in headache at all points except for at 18 and 60 months. This difference in improvement was not observed in patients undergoing single-level arthroplasty. The mechanism of greater headache relief after two-level arthroplasty remains unclear.
KW - cervical disk arthroplasty
KW - cervical fusion
KW - cervicogenic headache
KW - headache
UR - http://www.scopus.com/inward/record.url?scp=85020812457&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020812457&partnerID=8YFLogxK
U2 - 10.1055/s-0035-1570086
DO - 10.1055/s-0035-1570086
M3 - Article
AN - SCOPUS:85020812457
VL - 6
SP - 563
EP - 570
JO - Global Spine Journal
JF - Global Spine Journal
SN - 2192-5682
IS - 6
ER -