Abstract
Objective: This study examined the association between family history of completed suicide and suicidal behavior and other clinical variables in subjects with bipolar disorder. Method: 374 outpatients aged from 19 to 88 years (mean ± SD age = 41.9 ± 4.1 years) (54.3% female) meeting DSM-IV criteria for bipolar disorder type I or II or schizoaffective disorder, bipolar subtype, were included in the study. Forty-eight subjects with a family history of completed suicide were compared to 326 subjects without a family history of completed suicide regarding several clinical and demographic variables. The study was conducted from 2001 to 2004. Results: There were no statistically significant demographic differences between bipolar disorder subjects with and without a family history of suicide. Bipolar disorder subjects with a family history of suicide showed higher rates of cluster C personality disorders than subjects without a family history of suicide (14.9% vs. 2.5%, OR = 6.72, 95% CI = 2.31 to 19.51, p < .001). Subjects with a family history of suicide also demonstrated a significantly greater lifetime prevalence of suicide attempts (52.2% vs. 25.5%, OR = 3.19, 95% CI = 1.7 to 6.0, p < .001). Results remained significant after controlling for all possible interactions. Conclusion: Family history of completed suicide is a significant risk factor associated with suicidal attempts in patients with bipolar disorder. These findings underscore the importance of identifying patients with a family history of suicide in order to provide prompt treatment and careful follow-up.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1517-1521 |
| Number of pages | 5 |
| Journal | Journal of Clinical Psychiatry |
| Volume | 68 |
| Issue number | 10 |
| State | Published - Oct 2007 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology
Cite this
Relevance of family history of suicide in the long-term outcome of bipolar disorders. / Romero, Soledad; Colom, Francesc; Iosif, Ana-Maria; Cruz, Nuria; Pacchiaroti, Isabella; Sanchez-Moreno, Jose; Vieta, Eduard.
In: Journal of Clinical Psychiatry, Vol. 68, No. 10, 10.2007, p. 1517-1521.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relevance of family history of suicide in the long-term outcome of bipolar disorders
AU - Romero, Soledad
AU - Colom, Francesc
AU - Iosif, Ana-Maria
AU - Cruz, Nuria
AU - Pacchiaroti, Isabella
AU - Sanchez-Moreno, Jose
AU - Vieta, Eduard
PY - 2007/10
Y1 - 2007/10
N2 - Objective: This study examined the association between family history of completed suicide and suicidal behavior and other clinical variables in subjects with bipolar disorder. Method: 374 outpatients aged from 19 to 88 years (mean ± SD age = 41.9 ± 4.1 years) (54.3% female) meeting DSM-IV criteria for bipolar disorder type I or II or schizoaffective disorder, bipolar subtype, were included in the study. Forty-eight subjects with a family history of completed suicide were compared to 326 subjects without a family history of completed suicide regarding several clinical and demographic variables. The study was conducted from 2001 to 2004. Results: There were no statistically significant demographic differences between bipolar disorder subjects with and without a family history of suicide. Bipolar disorder subjects with a family history of suicide showed higher rates of cluster C personality disorders than subjects without a family history of suicide (14.9% vs. 2.5%, OR = 6.72, 95% CI = 2.31 to 19.51, p < .001). Subjects with a family history of suicide also demonstrated a significantly greater lifetime prevalence of suicide attempts (52.2% vs. 25.5%, OR = 3.19, 95% CI = 1.7 to 6.0, p < .001). Results remained significant after controlling for all possible interactions. Conclusion: Family history of completed suicide is a significant risk factor associated with suicidal attempts in patients with bipolar disorder. These findings underscore the importance of identifying patients with a family history of suicide in order to provide prompt treatment and careful follow-up.
AB - Objective: This study examined the association between family history of completed suicide and suicidal behavior and other clinical variables in subjects with bipolar disorder. Method: 374 outpatients aged from 19 to 88 years (mean ± SD age = 41.9 ± 4.1 years) (54.3% female) meeting DSM-IV criteria for bipolar disorder type I or II or schizoaffective disorder, bipolar subtype, were included in the study. Forty-eight subjects with a family history of completed suicide were compared to 326 subjects without a family history of completed suicide regarding several clinical and demographic variables. The study was conducted from 2001 to 2004. Results: There were no statistically significant demographic differences between bipolar disorder subjects with and without a family history of suicide. Bipolar disorder subjects with a family history of suicide showed higher rates of cluster C personality disorders than subjects without a family history of suicide (14.9% vs. 2.5%, OR = 6.72, 95% CI = 2.31 to 19.51, p < .001). Subjects with a family history of suicide also demonstrated a significantly greater lifetime prevalence of suicide attempts (52.2% vs. 25.5%, OR = 3.19, 95% CI = 1.7 to 6.0, p < .001). Results remained significant after controlling for all possible interactions. Conclusion: Family history of completed suicide is a significant risk factor associated with suicidal attempts in patients with bipolar disorder. These findings underscore the importance of identifying patients with a family history of suicide in order to provide prompt treatment and careful follow-up.
UR - http://www.scopus.com/inward/record.url?scp=35948935037&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35948935037&partnerID=8YFLogxK
M3 - Article
C2 - 17960965
AN - SCOPUS:35948935037
VL - 68
SP - 1517
EP - 1521
JO - Journal of Clinical Psychiatry
JF - Journal of Clinical Psychiatry
SN - 0160-6689
IS - 10
ER -