Relative uptake of low- and high-osmolality contrast media in CT of brain tumors

J. R. Fike, C. E. Cann, D. Norman, J. M. Turrel, Richard A Lecouteur, C. M. Pflugfelder, J. K. Borcich

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The magnitude and time course of contrast enhancement in spontaneous canine brain tumors was determined for two contrast agents: meglumine iothalamate and sodium meglumine ioxaglate. Tumor enhancement during contrast infusion and at 5, 10, 15, 30, and 45 min was measured using quantitative computed tomography. Blood iodine was measured using x-ray fluorescence. Peak contrast enhancement occurred during the infusion, and the magnitude was the same for both agents. Per gram of iodine infused, blood iodine was 12.4% higher with ioxaglate than iothalamate. The monoionic dimer ioxaglate is as effective as iothalamate for enhancement of canine brain tumors.

Original languageEnglish (US)
Pages (from-to)413-417
Number of pages5
JournalAmerican Journal of Neuroradiology
Issue number4
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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