Recent Chlamydia trachomatis isolates were tested in a tissue culture system for susceptibility to tetracycline, erythromycin, rosaramicin, rifampin, and clindamycin. Rifampin was the most active drug (minimal inhibitory concentration, ≤0.02 μg/ml). Tetracycline and rosaramicin were highly active, with a concentration of ≤0.25 μg/ml being chlamydicidal. Clindamycin was least active on a weight basis, requiring up to 16 μg/ml to prevent the passage of chlamydiae into a drug-free tissue culture system. Relative resistance to erythromycin was detected; two isolates were capable of limited replication in 1 μg/ml.
|Original language||English (US)|
|Number of pages||3|
|Journal||Antimicrobial Agents and Chemotherapy|
|State||Published - 1980|
ASJC Scopus subject areas
- Pharmacology (medical)