Relative resistance to erythromycin in Chlamydia trachomatis

A. Mourad, Richard L Sweet, N. Sugg, J. Schachter

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Abstract

Recent Chlamydia trachomatis isolates were tested in a tissue culture system for susceptibility to tetracycline, erythromycin, rosaramicin, rifampin, and clindamycin. Rifampin was the most active drug (minimal inhibitory concentration, ≤0.02 μg/ml). Tetracycline and rosaramicin were highly active, with a concentration of ≤0.25 μg/ml being chlamydicidal. Clindamycin was least active on a weight basis, requiring up to 16 μg/ml to prevent the passage of chlamydiae into a drug-free tissue culture system. Relative resistance to erythromycin was detected; two isolates were capable of limited replication in 1 μg/ml.

Original languageEnglish (US)
Pages (from-to)696-698
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume18
Issue number5
StatePublished - 1980

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ASJC Scopus subject areas

  • Pharmacology (medical)

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