Relative lesion detectability in 3D vs. 2D dedicated multi-ring PET

S. C. Moore, G. El Fakhri, Ramsey D Badawi, A. D. Van Den Abbeele, R. E. Zimmerman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Scopus citations


We estimated the detectability of spheres of different sizes but equal activity contrast, embedded in a clinically realistic phantom in order to compare two-dimensional (2D) and three-dimensional (3D) whole-body (WB) PET imaging for a relevant diagnostic task. Five plastic spheres with inside diameters of 0.8 to 3.4 cm, containing 74 kBq/ml of Ge-68, were placed in an anthropomorphic torso phantom. The background organs contained F-18 activity concentrations in appropriate physiologic proportions, as did a head phantom positioned outside the field of view (FOV) of our ECAT-HR+ system. The phantom was scanned for 9 hours at one bed position as the F-18 decayed from 97 to 3.2 kBq/ml. We obtained ten, 1-minute scans for each activity contrast level, alternating among three acquisitions: 2D mode with standard maximum ring difference (MRD=7), standard 3D mode (MRD=22), and 3D mode with MRD=13 (3D*). Images from 2D and 3D acquisitions were reconstructed by filtered backprojection and 3D reprojection (3DRP); 3D data were also reconstructed by FBP after Fourier rebinning (FORE+FBP). Sphere detectability was estimated using non-prewhitening (NPW) matched filtering to compute the detection signal-to-noise ratio, NPW SNR. In almost all cases, NPW-SNR was greater for 3D or 3D* than for 2D, although 2D outperformed 3D with 3DRP reconstruction at the earliest time points for two spheres located near opposite ends of the axial FOV; FORE+FBP reconstruction significantly improved the detectability of these spheres, compared to 3DRP, and demonstrated the expected near equivalence of 3D and 3D* data from spheres near the ends of the FOV. Our results were not predictable from global NEC considerations alone.

Original languageEnglish (US)
Title of host publicationIEEE Nuclear Science Symposium and Medical Imaging Conference
EditorsD. Merelli, J. Surget, M. Ulma
StatePublished - 2000
Externally publishedYes
Event2000 IEEE Nuclear Science Symposium Conference Record - Lyon, France
Duration: Oct 15 2000Oct 20 2000


Other2000 IEEE Nuclear Science Symposium Conference Record

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Industrial and Manufacturing Engineering


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