Relationships between thyroid indices and symptoms of anxiety in depressed outpatients

J. R. Magliozzi, Richard J Maddock, A. S. Gold, D. W. Gietzen

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Scores on rating scales measuring symptoms of depression, panic anxiety, state anxiety, trait anxiety, and agoraphobic avoidance were correlated, using multivariate statistics, with total thyroxine- and thyrotropin-releasing hormone concentrations in outpatients with major depression. A significant inverse relationship was demonstrated between agoraphobic avoidance and total thyroxine concentrations in female patients. No other symptom ratings were significantly associated with these thyroid indices. The depressed patients scored in the clinically significant range for agoraphobic symptoms. Assessment of agoraphobic avoidance may help identify a clinically and biologically distinct subgroup of depressed patients.

Original languageEnglish (US)
Pages (from-to)111-116
Number of pages6
JournalAnnals of Clinical Psychiatry
Issue number2
StatePublished - 1993


  • Agoraphobia
  • Panic disorder
  • Thyroid stimulating hormone (TSH)
  • Thyroxine

ASJC Scopus subject areas

  • Psychiatry and Mental health


Dive into the research topics of 'Relationships between thyroid indices and symptoms of anxiety in depressed outpatients'. Together they form a unique fingerprint.

Cite this