Relationships between the amount of weight loss and post-heparin lipoprotein lipase activity in patients with type II diabetes

Siddika E Karakas, L. L. Darga, J. H. Holden, S. Khilnani, S. Patton, K. L C Jen, C. P. Lucas

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The objective of this study was to investigate the changes in plasma post-heparin lipoprotein lipase activity, as it relates to the total amount of weight loss and the changes in plasma lipoproteins, during acute weight reduction and after weight maintenance in type II diabetic patients. Twenty-eight severely obese (mean weight = 106±21.7kg, BMI = 36.4±6.0kg/m2), diabetic patients lost, on the average, 13.3kg on a 500kcal (2100kJ) diet in eight weeks. Weight loss was maintained throughout the study, which lasted 24 weeks. At the baseline, post-heparin lipoprotein lipase activity did not correlate with degree of obesity, but correlated inversely with fasting plasma glucose (r=-0.64, P<0.0001) and triglyceride (r=-0.63, P<0.0001). Both during acute caloric restriction and after weight maintenance suppression in post-heparin lipoprotein lipase activity correlated directly with the amount of weight reduction (r=0.37, P<0.05 during weight loss and r=0.42, P<0.03 during weight maintenance). At the end of the study patients were divided into tertiles according to the amount of weight loss achieved and baseline characteristics of the highest and lowest weight loss groups were compared. Before weight loss, despite having similar weights, the highest weight loss group had higher lipoprotein lipase activity (211±32mU/ml vs 166±35mU/ml, P<0.05) and lower plasma triglyceride (1.64±0.62mmol/l vs 2.81±1.28mmol/l, P<0.05) as compared to the lowest weight loss group. At the end of the study, highest weight loss group had a significant (P<0.005) suppression of lipoprotein lipase (-84±38mU/ml), whereas the lowest weight loss group did not show any change (11±50mU/ml). These findings suggest that in severely obese type II diabetic patients, magnitude of total weight loss may be related to the activity of post-heparin lipoprotein lipase before the weight loss, as well as to the degree of suppression seen in this activity during the weight reduction period.

Original languageEnglish (US)
Pages (from-to)833-840
Number of pages8
JournalInternational Journal of Obesity
Issue number12
StatePublished - 1991
Externally publishedYes


  • Diabetes mellitus
  • Lipoprotein lipase
  • Weight loss

ASJC Scopus subject areas

  • Food Science
  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Public Health, Environmental and Occupational Health


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