Relationships between plasma-free fatty acid concentration, endogenous glucose production, and fasting hyperglycemia in normal and non-insulin-dependent diabetic individuals

A. Golay, Arthur L Swislocki, Y. D I Chen, G. M. Reaven

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144 Citations (Scopus)

Abstract

Measurements of fasting and postprandial plasma glucose, insulin, and free fatty acid (FFA) concentrations were made in 32 individuals-16 with normal glucose tolerance and 16 with non-insulin dependent diabetes mellitus (NIDDM)-further subdivided into two equal groups on the basis of body weight. In addition, endogenous glucose production was estimated in 32 subjects. Both fasting plasma glucose (251 ± 14 v 86 ± 1 mg/dL) and FFA (672 ± 35 v 434 ± 45 μEq/L) concentrations were significantly higher in patients with NIDDM (P < .001), and the differences between normal and diabetic existed in both weight groups. Rates of endogenous glucose production were also significantly elevated (P < .001) in diabetic (120 ± 6 mg/m2 × min) as compared to normal subjects (73 ± 6 mg/m2 × min), and these differences were also independent of degree of obesity. However, there were no significant differences between normal subjects and patients with NIDDM in either fasting or postprandial insulin concentrations. The similarity in insulin values for normal and diabetic subjects was true of both obesity groups, although insulin concentrations were somewhat higher in normal obese individuals as compared to their normal nonobese counterparts. Significant relationships were seen between values for fasting plasma glucose and endogenous glucose production (r = .89), fasting plasma glucose and fasting FFA (r = .64), and FFA levels and endogenous glucose production (r = .58) when all nonobese subjects were considered together. Essentially identical relationships, both qualitatively and quantitatively, were seen within the obese group. Thus, endogenous glucose production and plasma FFA concentrations are higher than normal in patients with NIDDM, and statistically significant relationships exist between plasma FFA concentration and both fasting plasma glucose concentration and endogenous glucose production.

Original languageEnglish (US)
Pages (from-to)692-696
Number of pages5
JournalMetabolism
Volume36
Issue number7
DOIs
StatePublished - 1987
Externally publishedYes

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Nonesterified Fatty Acids
Hyperglycemia
Fasting
Glucose
Type 2 Diabetes Mellitus
Insulin
Obesity
Reference Values
Body Weight
Weights and Measures

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

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title = "Relationships between plasma-free fatty acid concentration, endogenous glucose production, and fasting hyperglycemia in normal and non-insulin-dependent diabetic individuals",
abstract = "Measurements of fasting and postprandial plasma glucose, insulin, and free fatty acid (FFA) concentrations were made in 32 individuals-16 with normal glucose tolerance and 16 with non-insulin dependent diabetes mellitus (NIDDM)-further subdivided into two equal groups on the basis of body weight. In addition, endogenous glucose production was estimated in 32 subjects. Both fasting plasma glucose (251 ± 14 v 86 ± 1 mg/dL) and FFA (672 ± 35 v 434 ± 45 μEq/L) concentrations were significantly higher in patients with NIDDM (P < .001), and the differences between normal and diabetic existed in both weight groups. Rates of endogenous glucose production were also significantly elevated (P < .001) in diabetic (120 ± 6 mg/m2 × min) as compared to normal subjects (73 ± 6 mg/m2 × min), and these differences were also independent of degree of obesity. However, there were no significant differences between normal subjects and patients with NIDDM in either fasting or postprandial insulin concentrations. The similarity in insulin values for normal and diabetic subjects was true of both obesity groups, although insulin concentrations were somewhat higher in normal obese individuals as compared to their normal nonobese counterparts. Significant relationships were seen between values for fasting plasma glucose and endogenous glucose production (r = .89), fasting plasma glucose and fasting FFA (r = .64), and FFA levels and endogenous glucose production (r = .58) when all nonobese subjects were considered together. Essentially identical relationships, both qualitatively and quantitatively, were seen within the obese group. Thus, endogenous glucose production and plasma FFA concentrations are higher than normal in patients with NIDDM, and statistically significant relationships exist between plasma FFA concentration and both fasting plasma glucose concentration and endogenous glucose production.",
author = "A. Golay and Swislocki, {Arthur L} and Chen, {Y. D I} and Reaven, {G. M.}",
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T1 - Relationships between plasma-free fatty acid concentration, endogenous glucose production, and fasting hyperglycemia in normal and non-insulin-dependent diabetic individuals

AU - Golay, A.

AU - Swislocki, Arthur L

AU - Chen, Y. D I

AU - Reaven, G. M.

PY - 1987

Y1 - 1987

N2 - Measurements of fasting and postprandial plasma glucose, insulin, and free fatty acid (FFA) concentrations were made in 32 individuals-16 with normal glucose tolerance and 16 with non-insulin dependent diabetes mellitus (NIDDM)-further subdivided into two equal groups on the basis of body weight. In addition, endogenous glucose production was estimated in 32 subjects. Both fasting plasma glucose (251 ± 14 v 86 ± 1 mg/dL) and FFA (672 ± 35 v 434 ± 45 μEq/L) concentrations were significantly higher in patients with NIDDM (P < .001), and the differences between normal and diabetic existed in both weight groups. Rates of endogenous glucose production were also significantly elevated (P < .001) in diabetic (120 ± 6 mg/m2 × min) as compared to normal subjects (73 ± 6 mg/m2 × min), and these differences were also independent of degree of obesity. However, there were no significant differences between normal subjects and patients with NIDDM in either fasting or postprandial insulin concentrations. The similarity in insulin values for normal and diabetic subjects was true of both obesity groups, although insulin concentrations were somewhat higher in normal obese individuals as compared to their normal nonobese counterparts. Significant relationships were seen between values for fasting plasma glucose and endogenous glucose production (r = .89), fasting plasma glucose and fasting FFA (r = .64), and FFA levels and endogenous glucose production (r = .58) when all nonobese subjects were considered together. Essentially identical relationships, both qualitatively and quantitatively, were seen within the obese group. Thus, endogenous glucose production and plasma FFA concentrations are higher than normal in patients with NIDDM, and statistically significant relationships exist between plasma FFA concentration and both fasting plasma glucose concentration and endogenous glucose production.

AB - Measurements of fasting and postprandial plasma glucose, insulin, and free fatty acid (FFA) concentrations were made in 32 individuals-16 with normal glucose tolerance and 16 with non-insulin dependent diabetes mellitus (NIDDM)-further subdivided into two equal groups on the basis of body weight. In addition, endogenous glucose production was estimated in 32 subjects. Both fasting plasma glucose (251 ± 14 v 86 ± 1 mg/dL) and FFA (672 ± 35 v 434 ± 45 μEq/L) concentrations were significantly higher in patients with NIDDM (P < .001), and the differences between normal and diabetic existed in both weight groups. Rates of endogenous glucose production were also significantly elevated (P < .001) in diabetic (120 ± 6 mg/m2 × min) as compared to normal subjects (73 ± 6 mg/m2 × min), and these differences were also independent of degree of obesity. However, there were no significant differences between normal subjects and patients with NIDDM in either fasting or postprandial insulin concentrations. The similarity in insulin values for normal and diabetic subjects was true of both obesity groups, although insulin concentrations were somewhat higher in normal obese individuals as compared to their normal nonobese counterparts. Significant relationships were seen between values for fasting plasma glucose and endogenous glucose production (r = .89), fasting plasma glucose and fasting FFA (r = .64), and FFA levels and endogenous glucose production (r = .58) when all nonobese subjects were considered together. Essentially identical relationships, both qualitatively and quantitatively, were seen within the obese group. Thus, endogenous glucose production and plasma FFA concentrations are higher than normal in patients with NIDDM, and statistically significant relationships exist between plasma FFA concentration and both fasting plasma glucose concentration and endogenous glucose production.

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