Relationships among vitamin D levels, parathyroid hormone, and calcium absorption in young adolescents

Steven A. Abrams, Ian J. Griffin, Keli M. Hawthorne, Sheila K. Gunn, Caren M. Gundberg, Thomas O. Carpenter

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Background: Evidence suggests that vitamin D status in adults, as assessed by serum 25-hydroxyvitamin D (25-OHD), is positively associated with calcium absorption fraction and inversely associated with serum PTH. Few comparable pediatric data exist. Objectives: The objective of this study was to evaluate the relationships among vitamin D status, PTH, and calcium absorption in mid-pubertal boys and girls. Methods: Calcium absorption was measured as part of an evaluation of the effects of prebiotics (inulin-type fructans) using a stable isotope method in 93 young adolescents, 12.7 ± 1.0 yr of age, receiving diets averaging approximately 900 mg/d calcium. Results: A significant positive relation to calcium absorption was found for serum 1,25-dihydroxyvitamin D (P=0.048) and PTH (P=0.007), but not for 25-OHD (P = 0.77). PTH was significantly inversely related to 25-OHD and was positively related to serum 1,25-dihydroxyvitamin D and osteocalcin. PTH was marginally significantly inversely related to lumbar spinal, but not whole body, bone mineral density. Conclusions: These data suggest that in adolescents, especially in the presence of vitamin D insufficiency, PTH secretion increases to adapt to higher rates of bone formation associated with growth. This results in higher serum 1,25(OH)2D concentrations and increased calcium absorption results. Vitamin D status, as reflected by the serum 25-OHD level, is not closely related to calcium absorption. Whether adaptation to low serum 25-OHD is adequate under physiologically stressful situations, including those leading to very low serum 25-OHD levels, is unknown.

Original languageEnglish (US)
Pages (from-to)5576-5581
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume90
Issue number10
DOIs
StatePublished - Oct 2005
Externally publishedYes

Fingerprint

Parathyroid Hormone
Vitamin D
Calcium
Serum
Bone
Fructans
Prebiotics
Pediatrics
Inulin
Osteocalcin
Nutrition
Isotopes
Minerals
Osteogenesis
Bone Density
Diet
Growth

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Abrams, S. A., Griffin, I. J., Hawthorne, K. M., Gunn, S. K., Gundberg, C. M., & Carpenter, T. O. (2005). Relationships among vitamin D levels, parathyroid hormone, and calcium absorption in young adolescents. Journal of Clinical Endocrinology and Metabolism, 90(10), 5576-5581. https://doi.org/10.1210/jc.2005-1021

Relationships among vitamin D levels, parathyroid hormone, and calcium absorption in young adolescents. / Abrams, Steven A.; Griffin, Ian J.; Hawthorne, Keli M.; Gunn, Sheila K.; Gundberg, Caren M.; Carpenter, Thomas O.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 90, No. 10, 10.2005, p. 5576-5581.

Research output: Contribution to journalArticle

Abrams, Steven A. ; Griffin, Ian J. ; Hawthorne, Keli M. ; Gunn, Sheila K. ; Gundberg, Caren M. ; Carpenter, Thomas O. / Relationships among vitamin D levels, parathyroid hormone, and calcium absorption in young adolescents. In: Journal of Clinical Endocrinology and Metabolism. 2005 ; Vol. 90, No. 10. pp. 5576-5581.
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