Relationship of the uptake and β-oxidation of 18-carbon fatty acids with stimulation of murine mammary tumor cell growth

D. K. Buckman, Kent L Erickson

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The effects of stearic (18:0), oleic (18:1) and linoleic (18:2) acid on the in vitro growth of murine mammary tumor cell line 4526 were compared to 4526 uptake and β-oxidation of those fatty acids. Both 18:1 and 18:2 stimulated, while 18:0 inhibited growth. Likewise, uptake and oxidation rates were much lower for 18:0 than for 18:1 and 18:2. The influence of glucose, insulin and fatty acid-depletion on 4526 fatty acid incorporation and oxidation was also determined. The correlation between effects on in vitro growth and ability to assimilate 18:0, 18:1 and 18:2 may partially explain the stimulation by unsaturated and inhibition by saturated fatty acids of in vivo 4526 tumorigenesis.

Original languageEnglish (US)
Pages (from-to)257-265
Number of pages9
JournalCancer Letters
Volume59
Issue number3
DOIs
StatePublished - 1991

Keywords

  • fatty acids
  • murine mammary tumor cells
  • β-oxidation

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Fingerprint Dive into the research topics of 'Relationship of the uptake and β-oxidation of 18-carbon fatty acids with stimulation of murine mammary tumor cell growth'. Together they form a unique fingerprint.

  • Cite this