Relationship of seizure frequency to hippocampus volume and metabolism in temporal lobe epilepsy

M. V. Spanaki; L. Kopylev; K. Liow; Charles DeCarli; S. Fazilat; W. D. Gaillard; W. H. Theodore

Relationship of seizure frequency to hippocampus volume and metabolism in temporal lobe epilepsy

M. V. Spanaki, L. Kopylev, K. Liow, Charles DeCarli, S. Fazilat, W. D. Gaillard, W. H. Theodore

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To examine the relationship between frequency of complex partial (CPS) and secondarily generalized tonic-clonic seizures (sGTCS) on hippocampal volume (HV) and temporal lobe metabolism. Methods: We performed volumetric magnetic resonance imaging (MRI) and positron emission tomography with ¹⁸fluorodeoxyglucose (¹⁸FDG-PET) in 32 patients with epilepsy. Temporal lobe loci were localized by ictal video-EEG. Results: We did not find any association between CPS frequency or lifetime number of sGTCS and HV or metabolism ipsilateral to electroencephalographic focus. Conclusion: The progress of metabolic or pathologic abnormalities of temporal lobe epilepsy may not be altered by adequate seizure control. The presence of an epileptic focus might be associated with progressive neuronal injury even in clinically well-controlled patients.

Original language	English (US)
Pages (from-to)	1227-1229
Number of pages	3
Journal	Epilepsia
Volume	41
Issue number	9
State	Published - 2000
Externally published	Yes

Keywords

Epilepsy
Hippocampus
MRI
PET
Seizure frequency

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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@article{66ec758e84744f5fb0ce2b8430d8c84f,

title = "Relationship of seizure frequency to hippocampus volume and metabolism in temporal lobe epilepsy",

abstract = "Purpose: To examine the relationship between frequency of complex partial (CPS) and secondarily generalized tonic-clonic seizures (sGTCS) on hippocampal volume (HV) and temporal lobe metabolism. Methods: We performed volumetric magnetic resonance imaging (MRI) and positron emission tomography with 18fluorodeoxyglucose (18FDG-PET) in 32 patients with epilepsy. Temporal lobe loci were localized by ictal video-EEG. Results: We did not find any association between CPS frequency or lifetime number of sGTCS and HV or metabolism ipsilateral to electroencephalographic focus. Conclusion: The progress of metabolic or pathologic abnormalities of temporal lobe epilepsy may not be altered by adequate seizure control. The presence of an epileptic focus might be associated with progressive neuronal injury even in clinically well-controlled patients.",

keywords = "Epilepsy, Hippocampus, MRI, PET, Seizure frequency",

author = "Spanaki, {M. V.} and L. Kopylev and K. Liow and Charles DeCarli and S. Fazilat and Gaillard, {W. D.} and Theodore, {W. H.}",

year = "2000",

language = "English (US)",

volume = "41",

pages = "1227--1229",

journal = "Epilepsia",

issn = "0013-9580",

publisher = "Wiley-Blackwell",

number = "9",

}

TY - JOUR

T1 - Relationship of seizure frequency to hippocampus volume and metabolism in temporal lobe epilepsy

AU - Spanaki, M. V.

AU - Kopylev, L.

AU - Liow, K.

AU - DeCarli, Charles

AU - Fazilat, S.

AU - Gaillard, W. D.

AU - Theodore, W. H.

PY - 2000

Y1 - 2000

N2 - Purpose: To examine the relationship between frequency of complex partial (CPS) and secondarily generalized tonic-clonic seizures (sGTCS) on hippocampal volume (HV) and temporal lobe metabolism. Methods: We performed volumetric magnetic resonance imaging (MRI) and positron emission tomography with 18fluorodeoxyglucose (18FDG-PET) in 32 patients with epilepsy. Temporal lobe loci were localized by ictal video-EEG. Results: We did not find any association between CPS frequency or lifetime number of sGTCS and HV or metabolism ipsilateral to electroencephalographic focus. Conclusion: The progress of metabolic or pathologic abnormalities of temporal lobe epilepsy may not be altered by adequate seizure control. The presence of an epileptic focus might be associated with progressive neuronal injury even in clinically well-controlled patients.

AB - Purpose: To examine the relationship between frequency of complex partial (CPS) and secondarily generalized tonic-clonic seizures (sGTCS) on hippocampal volume (HV) and temporal lobe metabolism. Methods: We performed volumetric magnetic resonance imaging (MRI) and positron emission tomography with 18fluorodeoxyglucose (18FDG-PET) in 32 patients with epilepsy. Temporal lobe loci were localized by ictal video-EEG. Results: We did not find any association between CPS frequency or lifetime number of sGTCS and HV or metabolism ipsilateral to electroencephalographic focus. Conclusion: The progress of metabolic or pathologic abnormalities of temporal lobe epilepsy may not be altered by adequate seizure control. The presence of an epileptic focus might be associated with progressive neuronal injury even in clinically well-controlled patients.

KW - Epilepsy

KW - Hippocampus

KW - MRI

KW - PET

KW - Seizure frequency

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JO - Epilepsia

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