Relationship of postprandial nonesterified fatty acids, adipokines, and insulin across gender in human immunodeficiency virus-positive patients undergoing highly active antiretroviral therapy

Guijing Lu, Asha Thomas-Geevarghese, Anuurad Erdembileg, Subhashree Raghavan, Robert Minolfo, Bernard Ormsby, Wahida Karmally, Wafaa M. El-Sadr, Jeanine Albu, Lars Berglund

Research output: Contribution to journalArticle

Abstract

Background: Metabolic derangements are common in human immunodeficiency virus (HIV)-positive subjects undergoing antiretroviral therapy, but little is known about postprandial conditions. Methods: We investigated the relationship between leptin, adiponectin, nonesterified fatty acids (NEFA), and insulin in response to a day-long meal pattern and evaluated gender differences in HIV-positive men (n = 12) and women (n = 13) undergoing highly active antiretroviral therapy (HAART). Results: For both men and women, a significant decrease in postprandial NEFA levels was observed following breakfast (0.53 vs. 0.22 mmol/L, P < 0.001, baseline and at 3 hours, respectively), whereas day-long postprandial leptin and adiponectin levels showed small nonsignificant oscillations. In contrast to NEFA and adiponectin, postprandial leptin levels were significantly higher among women compared to men (P < 0.05). Postprandial NEFA levels correlated positively with fasting insulin levels (r 2 = 0.25, P = 0.016), and the postbreakfast decrease in NEFA levels correlated significantly with the postbreakfast increase in insulin levels (r 2 = 0.17, P = 0.038). No significant association between postprandial adipokines and insulin was observed. Conclusions: In HAART-treated, HIV-infected men and women, levels of NEFA, but not adipokines, showed significant postprandial variation. Furthermore, food intake resulted in significant NEFA suppression in proportion to the food-stimulated insulin increase.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalMetabolic Syndrome and Related Disorders
Volume7
Issue number3
DOIs
StatePublished - Jun 1 2009

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Adipokines
Highly Active Antiretroviral Therapy
Nonesterified Fatty Acids
HIV
Insulin
Adiponectin
Leptin
Breakfast
Meals
Fasting
Eating
Food

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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Relationship of postprandial nonesterified fatty acids, adipokines, and insulin across gender in human immunodeficiency virus-positive patients undergoing highly active antiretroviral therapy. / Lu, Guijing; Thomas-Geevarghese, Asha; Erdembileg, Anuurad; Raghavan, Subhashree; Minolfo, Robert; Ormsby, Bernard; Karmally, Wahida; El-Sadr, Wafaa M.; Albu, Jeanine; Berglund, Lars.

In: Metabolic Syndrome and Related Disorders, Vol. 7, No. 3, 01.06.2009, p. 199-204.

Research output: Contribution to journalArticle

Lu, Guijing ; Thomas-Geevarghese, Asha ; Erdembileg, Anuurad ; Raghavan, Subhashree ; Minolfo, Robert ; Ormsby, Bernard ; Karmally, Wahida ; El-Sadr, Wafaa M. ; Albu, Jeanine ; Berglund, Lars. / Relationship of postprandial nonesterified fatty acids, adipokines, and insulin across gender in human immunodeficiency virus-positive patients undergoing highly active antiretroviral therapy. In: Metabolic Syndrome and Related Disorders. 2009 ; Vol. 7, No. 3. pp. 199-204.
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AU - Thomas-Geevarghese, Asha

AU - Erdembileg, Anuurad

AU - Raghavan, Subhashree

AU - Minolfo, Robert

AU - Ormsby, Bernard

AU - Karmally, Wahida

AU - El-Sadr, Wafaa M.

AU - Albu, Jeanine

AU - Berglund, Lars

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AB - Background: Metabolic derangements are common in human immunodeficiency virus (HIV)-positive subjects undergoing antiretroviral therapy, but little is known about postprandial conditions. Methods: We investigated the relationship between leptin, adiponectin, nonesterified fatty acids (NEFA), and insulin in response to a day-long meal pattern and evaluated gender differences in HIV-positive men (n = 12) and women (n = 13) undergoing highly active antiretroviral therapy (HAART). Results: For both men and women, a significant decrease in postprandial NEFA levels was observed following breakfast (0.53 vs. 0.22 mmol/L, P < 0.001, baseline and at 3 hours, respectively), whereas day-long postprandial leptin and adiponectin levels showed small nonsignificant oscillations. In contrast to NEFA and adiponectin, postprandial leptin levels were significantly higher among women compared to men (P < 0.05). Postprandial NEFA levels correlated positively with fasting insulin levels (r 2 = 0.25, P = 0.016), and the postbreakfast decrease in NEFA levels correlated significantly with the postbreakfast increase in insulin levels (r 2 = 0.17, P = 0.038). No significant association between postprandial adipokines and insulin was observed. Conclusions: In HAART-treated, HIV-infected men and women, levels of NEFA, but not adipokines, showed significant postprandial variation. Furthermore, food intake resulted in significant NEFA suppression in proportion to the food-stimulated insulin increase.

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