Relationship of normal serum vitamin B12 and folate levels to cognitive test performance in subtypes of geriatric major depression

I. R. Bell, J. S. Edman, J. Miller, N. Hebben, R. T. Linn, D. Ray, H. L. Kayne

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

This retrospective study evaluated the relationships between normal serum vitamin B12 and folate levels and neuropsychologic measures in a sample of 60 geriatric inpatients with psychotic depression, nonpsychotic depression, bipolar disorder, and dementia - all consecutively referred for cognitive testing. The psychotic depression subgroup demonstrated numerous significant positive correlations between B12 and cognitive subtests not seen in other diagnostic subgroups, especially those of IQ, and verbal and visual memory. Metabolic factors including vitamin B12 may play specific roles in the cognitive dysfunctions of different geropsychiatric disorders.

Original languageEnglish (US)
Pages (from-to)98-105
Number of pages8
JournalJournal of Geriatric Psychiatry and Neurology
Volume3
Issue number2
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

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