Relationship of interferon-inducing particle phenotype to encephalomyocarditis virus-induced diabetic mellitus

Stuart H Cohen, V. Bolton, G. W. Jordan

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The B (nondiabetogenic) and D (diabetogenic) variants of encephalomyocarditis (EMC) virus were studied to further define the role of the interferon (IFN) system in murine virus-induced diabetes mellitus. The relationship between the initial multiplicity of infection with EMC-B and the IFN yield showed that cells infected with one IFN-inducing particle produce a maximum amount of IFN, whereas IFN production is suppressed in cells infected with two or more particles. The IFN yield induced by EMC-D was less than 5% of that induced by EMC-B, allowing the designation of the B and D variants as Ifp+ and Ifp-, respectively. The Ifp+ property of the virion was shown to be responsible for the greater sensitivity of EMC-B to exogenous IFN as a result of primed local IFN induction. The data indicate that different Ifp phenotypes occur in nature and are associated with the development of diabetes in mice.

Original languageEnglish (US)
Pages (from-to)605-611
Number of pages7
JournalInfection and Immunity
Volume42
Issue number2
StatePublished - 1983

ASJC Scopus subject areas

  • Immunology

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