Relationship between TNF-α signaling pathway and the function of CD4+ T cell subsets in rheumatoid arthritis

Bei Huang, Qingtong Wang, Kang Kang Liu, Ling Jiang, Wei Wei

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

CD4+ T cell subsets play different roles in the pathogenesis of rheumatoid arthritis (RA). The helper T (Th1)/Th2 and Th17/regulatory T cells (Treg) imbalance and pro-inflammatory cytokines, such as interleukin-1 (IL-1), IL-2, interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α), are the key factors in the chronic inflammation of RA. TNF-α interacts with two different receptors, designated TNF receptor 1 (TNFR1) and TNFR2, which are expressed in different cells and tissues. TNFR1 is expressed in most cells. However, TNFR2 is only expressed in T cells and other immune cells which regulate the survival, activation and proliferation of T-lymphocytes. This review summarizes the relationship between TNF-α signaling pathway and the function of CD4+ T cell subsets in the pathogenesis of RA in an attempt to provide new ideas for the treatment of RA.

Original languageEnglish (US)
Pages (from-to)900-903
Number of pages4
JournalChinese Pharmacological Bulletin
Volume29
Issue number7
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Keywords

  • Cytokines
  • Interaction
  • Rheumatoid arthritis
  • Signaling pathway
  • TNF-α

ASJC Scopus subject areas

  • Pharmacology

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