CD4+ T cell subsets play different roles in the pathogenesis of rheumatoid arthritis (RA). The helper T (Th1)/Th2 and Th17/regulatory T cells (Treg) imbalance and pro-inflammatory cytokines, such as interleukin-1 (IL-1), IL-2, interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α), are the key factors in the chronic inflammation of RA. TNF-α interacts with two different receptors, designated TNF receptor 1 (TNFR1) and TNFR2, which are expressed in different cells and tissues. TNFR1 is expressed in most cells. However, TNFR2 is only expressed in T cells and other immune cells which regulate the survival, activation and proliferation of T-lymphocytes. This review summarizes the relationship between TNF-α signaling pathway and the function of CD4+ T cell subsets in the pathogenesis of RA in an attempt to provide new ideas for the treatment of RA.
|Original language||English (US)|
|Number of pages||4|
|Journal||Chinese Pharmacological Bulletin|
|State||Published - Jan 1 2013|
- Rheumatoid arthritis
- Signaling pathway
ASJC Scopus subject areas