Relationship between the effects of total glucosides of paeony on expression of β-arrestins and inhibition on synoviocyte proliferation from CIA rats

Hua Xun Wu; Jing Yu Chen; Qingtong Wang; Wu Yi Sun; Yan Chang; Yu Jing Wu; Ling Ling Zhang; Wei Wei

doi:10.3969/j.issn.1001-1978.2012.07.012

Relationship between the effects of total glucosides of paeony on expression of β-arrestins and inhibition on synoviocyte proliferation from CIA rats

Hua Xun Wu, Jing Yu Chen, Qingtong Wang, Wu Yi Sun, Yan Chang, Yu Jing Wu, Ling Ling Zhang, Wei Wei

Research output: Contribution to journal › Article

2 Scopus citations

Abstract

Aim: To elucidate the correlation between effects of total glucosides of paeony (TGP) on expression of β-arrestins and inhibition on synoviocyte proliferation from CIA rats. Methods: CIA model in rats was induced by injection of chicken type II collagen (CCII) emulsion. TGP (25, 50, 100 mg·kg ^-1·d^-1) was adminisered intragastricly to CIA rats during d 14 ∼ 28. Synoviocyte proliferation was determined by MTT assay. The expression of β-arrestins in synoviocytes from CIA rats was measured by Western blot. Results: TGP (25, 50, 100 mg·kg^-1, ig, d 14 ∼ 28) could inhibit synoviocyte proliferation and reduce the expression of β-arrestin 2 greatly in synovial tissue of CIA rats. The effects of TGP on the expression of β-arrestin 2 had a positive correlation with the inhibition of TGP on synoviocyte proliferation. Conclusion: TGP can inhibit synoviocyte proliferation of CIA rats, which may be related to downregulating the expression of β-arrestin 2.

Original language	English (US)
Pages (from-to)	934-937
Number of pages	4
Journal	Chinese Pharmacological Bulletin
Volume	28
Issue number	7
DOIs	https://doi.org/10.3969/j.issn.1001-1978.2012.07.012
State	Published - Jan 1 2012
Externally published	Yes

Keywords

Collagen-induced arthritis
Fibroblast-like synoviocyte
G-protein-coupled receptors
Rheumatoid arthritis
Total glucosides of paeony
β-arrestins

ASJC Scopus subject areas

Pharmacology

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Wu, H. X., Chen, J. Y., Wang, Q., Sun, W. Y., Chang, Y., Wu, Y. J., Zhang, L. L., & Wei, W. (2012). Relationship between the effects of total glucosides of paeony on expression of β-arrestins and inhibition on synoviocyte proliferation from CIA rats. Chinese Pharmacological Bulletin, 28(7), 934-937. https://doi.org/10.3969/j.issn.1001-1978.2012.07.012

Relationship between the effects of total glucosides of paeony on expression of β-arrestins and inhibition on synoviocyte proliferation from CIA rats. / Wu, Hua Xun; Chen, Jing Yu; Wang, Qingtong; Sun, Wu Yi; Chang, Yan; Wu, Yu Jing; Zhang, Ling Ling; Wei, Wei.

In: Chinese Pharmacological Bulletin, Vol. 28, No. 7, 01.01.2012, p. 934-937.

Research output: Contribution to journal › Article

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abstract = "Aim: To elucidate the correlation between effects of total glucosides of paeony (TGP) on expression of β-arrestins and inhibition on synoviocyte proliferation from CIA rats. Methods: CIA model in rats was induced by injection of chicken type II collagen (CCII) emulsion. TGP (25, 50, 100 mg·kg -1·d-1) was adminisered intragastricly to CIA rats during d 14 ∼ 28. Synoviocyte proliferation was determined by MTT assay. The expression of β-arrestins in synoviocytes from CIA rats was measured by Western blot. Results: TGP (25, 50, 100 mg·kg-1, ig, d 14 ∼ 28) could inhibit synoviocyte proliferation and reduce the expression of β-arrestin 2 greatly in synovial tissue of CIA rats. The effects of TGP on the expression of β-arrestin 2 had a positive correlation with the inhibition of TGP on synoviocyte proliferation. Conclusion: TGP can inhibit synoviocyte proliferation of CIA rats, which may be related to downregulating the expression of β-arrestin 2.",

keywords = "Collagen-induced arthritis, Fibroblast-like synoviocyte, G-protein-coupled receptors, Rheumatoid arthritis, Total glucosides of paeony, β-arrestins",

author = "Wu, {Hua Xun} and Chen, {Jing Yu} and Qingtong Wang and Sun, {Wu Yi} and Yan Chang and Wu, {Yu Jing} and Zhang, {Ling Ling} and Wei Wei",

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AU - Sun, Wu Yi

AU - Chang, Yan

AU - Wu, Yu Jing

AU - Zhang, Ling Ling

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AB - Aim: To elucidate the correlation between effects of total glucosides of paeony (TGP) on expression of β-arrestins and inhibition on synoviocyte proliferation from CIA rats. Methods: CIA model in rats was induced by injection of chicken type II collagen (CCII) emulsion. TGP (25, 50, 100 mg·kg -1·d-1) was adminisered intragastricly to CIA rats during d 14 ∼ 28. Synoviocyte proliferation was determined by MTT assay. The expression of β-arrestins in synoviocytes from CIA rats was measured by Western blot. Results: TGP (25, 50, 100 mg·kg-1, ig, d 14 ∼ 28) could inhibit synoviocyte proliferation and reduce the expression of β-arrestin 2 greatly in synovial tissue of CIA rats. The effects of TGP on the expression of β-arrestin 2 had a positive correlation with the inhibition of TGP on synoviocyte proliferation. Conclusion: TGP can inhibit synoviocyte proliferation of CIA rats, which may be related to downregulating the expression of β-arrestin 2.

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