Abstract
Aim: To elucidate the correlation between effects of total glucosides of paeony (TGP) on expression of β-arrestins and inhibition on synoviocyte proliferation from CIA rats. Methods: CIA model in rats was induced by injection of chicken type II collagen (CCII) emulsion. TGP (25, 50, 100 mg·kg -1·d-1) was adminisered intragastricly to CIA rats during d 14 ∼ 28. Synoviocyte proliferation was determined by MTT assay. The expression of β-arrestins in synoviocytes from CIA rats was measured by Western blot. Results: TGP (25, 50, 100 mg·kg-1, ig, d 14 ∼ 28) could inhibit synoviocyte proliferation and reduce the expression of β-arrestin 2 greatly in synovial tissue of CIA rats. The effects of TGP on the expression of β-arrestin 2 had a positive correlation with the inhibition of TGP on synoviocyte proliferation. Conclusion: TGP can inhibit synoviocyte proliferation of CIA rats, which may be related to downregulating the expression of β-arrestin 2.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 934-937 |
| Number of pages | 4 |
| Journal | Chinese Pharmacological Bulletin |
| Volume | 28 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jan 1 2012 |
| Externally published | Yes |
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Keywords
- Collagen-induced arthritis
- Fibroblast-like synoviocyte
- G-protein-coupled receptors
- Rheumatoid arthritis
- Total glucosides of paeony
- β-arrestins
ASJC Scopus subject areas
- Pharmacology
Cite this
Relationship between the effects of total glucosides of paeony on expression of β-arrestins and inhibition on synoviocyte proliferation from CIA rats. / Wu, Hua Xun; Chen, Jing Yu; Wang, Qingtong; Sun, Wu Yi; Chang, Yan; Wu, Yu Jing; Zhang, Ling Ling; Wei, Wei.
In: Chinese Pharmacological Bulletin, Vol. 28, No. 7, 01.01.2012, p. 934-937.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relationship between the effects of total glucosides of paeony on expression of β-arrestins and inhibition on synoviocyte proliferation from CIA rats
AU - Wu, Hua Xun
AU - Chen, Jing Yu
AU - Wang, Qingtong
AU - Sun, Wu Yi
AU - Chang, Yan
AU - Wu, Yu Jing
AU - Zhang, Ling Ling
AU - Wei, Wei
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Aim: To elucidate the correlation between effects of total glucosides of paeony (TGP) on expression of β-arrestins and inhibition on synoviocyte proliferation from CIA rats. Methods: CIA model in rats was induced by injection of chicken type II collagen (CCII) emulsion. TGP (25, 50, 100 mg·kg -1·d-1) was adminisered intragastricly to CIA rats during d 14 ∼ 28. Synoviocyte proliferation was determined by MTT assay. The expression of β-arrestins in synoviocytes from CIA rats was measured by Western blot. Results: TGP (25, 50, 100 mg·kg-1, ig, d 14 ∼ 28) could inhibit synoviocyte proliferation and reduce the expression of β-arrestin 2 greatly in synovial tissue of CIA rats. The effects of TGP on the expression of β-arrestin 2 had a positive correlation with the inhibition of TGP on synoviocyte proliferation. Conclusion: TGP can inhibit synoviocyte proliferation of CIA rats, which may be related to downregulating the expression of β-arrestin 2.
AB - Aim: To elucidate the correlation between effects of total glucosides of paeony (TGP) on expression of β-arrestins and inhibition on synoviocyte proliferation from CIA rats. Methods: CIA model in rats was induced by injection of chicken type II collagen (CCII) emulsion. TGP (25, 50, 100 mg·kg -1·d-1) was adminisered intragastricly to CIA rats during d 14 ∼ 28. Synoviocyte proliferation was determined by MTT assay. The expression of β-arrestins in synoviocytes from CIA rats was measured by Western blot. Results: TGP (25, 50, 100 mg·kg-1, ig, d 14 ∼ 28) could inhibit synoviocyte proliferation and reduce the expression of β-arrestin 2 greatly in synovial tissue of CIA rats. The effects of TGP on the expression of β-arrestin 2 had a positive correlation with the inhibition of TGP on synoviocyte proliferation. Conclusion: TGP can inhibit synoviocyte proliferation of CIA rats, which may be related to downregulating the expression of β-arrestin 2.
KW - Collagen-induced arthritis
KW - Fibroblast-like synoviocyte
KW - G-protein-coupled receptors
KW - Rheumatoid arthritis
KW - Total glucosides of paeony
KW - β-arrestins
UR - http://www.scopus.com/inward/record.url?scp=84865680247&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865680247&partnerID=8YFLogxK
U2 - 10.3969/j.issn.1001-1978.2012.07.012
DO - 10.3969/j.issn.1001-1978.2012.07.012
M3 - Article
AN - SCOPUS:84865680247
VL - 28
SP - 934
EP - 937
JO - Chinese Pharmacological Bulletin
JF - Chinese Pharmacological Bulletin
SN - 1001-1978
IS - 7
ER -