Abstract
Objective: Most studies suggest that hysterectomies are more common in African American women than in other ethnic groups. To assess this ethnic surgical disparity in a novel way, our main goal was to determine whether admixture (the proportion of sub-Saharan African or European origin in individuals) is associated with hysterectomy frequency in African American women in the Women's Health Initiative. Study Design: In this retrospective study, we used ancestry informative single nucleotide polymorphisms to estimate admixture proportions in >10,000 African American women from the Women's Health Initiative. Logistic regression models were used to assess the association between admixture and self-reported history of hysterectomy with and without controls for relevant covariates. Multinomial logistic regression models were used to assess the association between admixture and self-reported age of hysterectomy. We also considered other potential risk factors (adiposity, hypertension, and education) for hysterectomy accounting for admixture. Results: African admixture was a strong risk factor after the adjustment for multiple covariates (odds ratio, 1.85; P <.0001). The admixture risk for hysterectomy was highest for those procedures that were performed in the 35-39 age range (odds ratio, 3.08; P <.0001) and least evident in oldest ages (≥45 years old). Our analyses also suggest that adiposity, hypertension, and education were associated independently with hysterectomy in this population group. Conclusion: These results suggest that higher African admixture is associated with higher frequencies of hysterectomy and that genetic studies that specifically target African American women and diseases that are associated with hysterectomy may be especially useful in understanding the pathogenesis and underlying cause of this disparity in health outcome.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 208 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2013 |
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Keywords
- ancestry
- ancestry informative markers
- fibroid tumors
- Women's Health Initiative
ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Relationship between hysterectomy and admixture in African American women. / Qi, Lihong; Nassir, Rami; Kosoy, Roman; Garcia, Lorena; Waetjen, L Elaine; Ochs-Balcom, Heather M.; Gass, Margery; Robbins, John A; Seldin, Michael F.
In: American Journal of Obstetrics and Gynecology, Vol. 208, No. 4, 04.2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relationship between hysterectomy and admixture in African American women
AU - Qi, Lihong
AU - Nassir, Rami
AU - Kosoy, Roman
AU - Garcia, Lorena
AU - Waetjen, L Elaine
AU - Ochs-Balcom, Heather M.
AU - Gass, Margery
AU - Robbins, John A
AU - Seldin, Michael F
PY - 2013/4
Y1 - 2013/4
N2 - Objective: Most studies suggest that hysterectomies are more common in African American women than in other ethnic groups. To assess this ethnic surgical disparity in a novel way, our main goal was to determine whether admixture (the proportion of sub-Saharan African or European origin in individuals) is associated with hysterectomy frequency in African American women in the Women's Health Initiative. Study Design: In this retrospective study, we used ancestry informative single nucleotide polymorphisms to estimate admixture proportions in >10,000 African American women from the Women's Health Initiative. Logistic regression models were used to assess the association between admixture and self-reported history of hysterectomy with and without controls for relevant covariates. Multinomial logistic regression models were used to assess the association between admixture and self-reported age of hysterectomy. We also considered other potential risk factors (adiposity, hypertension, and education) for hysterectomy accounting for admixture. Results: African admixture was a strong risk factor after the adjustment for multiple covariates (odds ratio, 1.85; P <.0001). The admixture risk for hysterectomy was highest for those procedures that were performed in the 35-39 age range (odds ratio, 3.08; P <.0001) and least evident in oldest ages (≥45 years old). Our analyses also suggest that adiposity, hypertension, and education were associated independently with hysterectomy in this population group. Conclusion: These results suggest that higher African admixture is associated with higher frequencies of hysterectomy and that genetic studies that specifically target African American women and diseases that are associated with hysterectomy may be especially useful in understanding the pathogenesis and underlying cause of this disparity in health outcome.
AB - Objective: Most studies suggest that hysterectomies are more common in African American women than in other ethnic groups. To assess this ethnic surgical disparity in a novel way, our main goal was to determine whether admixture (the proportion of sub-Saharan African or European origin in individuals) is associated with hysterectomy frequency in African American women in the Women's Health Initiative. Study Design: In this retrospective study, we used ancestry informative single nucleotide polymorphisms to estimate admixture proportions in >10,000 African American women from the Women's Health Initiative. Logistic regression models were used to assess the association between admixture and self-reported history of hysterectomy with and without controls for relevant covariates. Multinomial logistic regression models were used to assess the association between admixture and self-reported age of hysterectomy. We also considered other potential risk factors (adiposity, hypertension, and education) for hysterectomy accounting for admixture. Results: African admixture was a strong risk factor after the adjustment for multiple covariates (odds ratio, 1.85; P <.0001). The admixture risk for hysterectomy was highest for those procedures that were performed in the 35-39 age range (odds ratio, 3.08; P <.0001) and least evident in oldest ages (≥45 years old). Our analyses also suggest that adiposity, hypertension, and education were associated independently with hysterectomy in this population group. Conclusion: These results suggest that higher African admixture is associated with higher frequencies of hysterectomy and that genetic studies that specifically target African American women and diseases that are associated with hysterectomy may be especially useful in understanding the pathogenesis and underlying cause of this disparity in health outcome.
KW - ancestry
KW - ancestry informative markers
KW - fibroid tumors
KW - Women's Health Initiative
UR - http://www.scopus.com/inward/record.url?scp=84875474290&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875474290&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2013.01.027
DO - 10.1016/j.ajog.2013.01.027
M3 - Article
C2 - 23333549
AN - SCOPUS:84875474290
VL - 208
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 4
ER -