Relationship between dietary phytoestrogens and development of urinary incontinence in midlife women

L Elaine Waetjen, Katherine Leung, Sybil L. Crawford, Mei Hua Huang, Ellen B Gold, Gail A. Greendale

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Because exogenous estrogen treatment has been associated with a higher risk of urinary incontinence, our objective was to evaluate the longitudinal relationships of dietary phytoestrogen intakes (isoflavones, coumestans, and lignans) and the development of incontinence in midlife women transitioning through menopause. METHODS: The Study of Women's Health Across the Nation (SWAN) Phytoestrogen Study was developed within SWAN, a community-based, multisite, multiracial/ethnic, prospective cohort study. SWAN interviewers administered a food consumption assessment at baseline and on follow-up visits 5 and 9. The SWAN Phytoestrogen Study created a phytonutrient database that allowed estimation of the usual daily intakes of four isoflavones, four lignans, and coumestrol. On an annual self-administered questionnaire, participants reported on the frequency and type of incontinence. We used discrete proportional hazards models to evaluate whether the estimated daily intake of each phytoestrogen class on the visit previous to the first report of incontinence was associated with the development of monthly or more incontinence versus remaining continent. RESULTS: We found no association or patterns of association between developing any, stress, or urge incontinence and the reported daily dietary intake of isoflavones, coumestrol, and lignans on the visit previous to the onset of incontinence. CONCLUSIONS: The results of this longitudinal study provide important information to better understand estrogenlike substances in the continence mechanism of midlife women. Our study shows that neither high nor low dietary intakes of isoflavones, coumestrol, and lignans prevent stress or urge incontinence. Future studies should evaluate whether serum levels of phytoestrogens or their metabolites impact incontinence symptoms.

Original languageEnglish (US)
Pages (from-to)428-436
Number of pages9
JournalMenopause
Volume20
Issue number4
DOIs
StatePublished - Apr 2013

Fingerprint

Phytoestrogens
Urinary Incontinence
Lignans
Isoflavones
Coumestrol
Women's Health
Urge Urinary Incontinence
Phytochemicals
Menopause
Proportional Hazards Models
Longitudinal Studies
Estrogens
Cohort Studies
Databases
Prospective Studies
Interviews
Food
Serum

Keywords

  • Coumestrol
  • Isoflavone
  • Lignan
  • Phytoestrogen
  • Urinary incontinence

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Relationship between dietary phytoestrogens and development of urinary incontinence in midlife women. / Waetjen, L Elaine; Leung, Katherine; Crawford, Sybil L.; Huang, Mei Hua; Gold, Ellen B; Greendale, Gail A.

In: Menopause, Vol. 20, No. 4, 04.2013, p. 428-436.

Research output: Contribution to journalArticle

Waetjen, L Elaine ; Leung, Katherine ; Crawford, Sybil L. ; Huang, Mei Hua ; Gold, Ellen B ; Greendale, Gail A. / Relationship between dietary phytoestrogens and development of urinary incontinence in midlife women. In: Menopause. 2013 ; Vol. 20, No. 4. pp. 428-436.
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