Relationship between circadian rhythm of body temperature and weight loss in aging rats

R. B. McDonald, C. M. Murtagh-Mark, C. A. Fuller, T. M. Hoban-Higgins, Barbara A Horwitz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Previous investigations indicate that the aging Fischer 344 (F344) rat undergoes a transition from aging to senescence which is characterized by a rapid decline in body weight and the development of severe cold-induced hypothermia. These observations suggest that the transition from gradual aging to senescence involves general alterations in hypothalamic function. To further investigate this possibility, circadian rhythm of body temperature (CRT) was measured in male F344 rats beginning at age 23 mo. and followed continuously until death via a temperature-sensing radio wave transmitter implanted in the abdominal cavity. The rats were maintained in a room with constant dim light (10-15 lux) at a thermoneutral temperature (24-25°C). Temperature was recorded every 10 mins. Body weights were measured bi-weekly. The age at which body weight displayed a rapid decline ranged from 24 to 32 mo. In general, rats died within 3 weeks of the onset of rapid weight loss. Measures of CRT, daily mean body temperature, rhythm period and amplitude did not differ significantly within each rat during aie period that body weight was stable. However, at the onset of rapid weight loss, daily mean temperature and rhythm amplitude decreased; changes in the period response were inconsistent These data suggest that the altered CRT of aging rats is associated more closely with the transition to senescence (as indicated by the rapid decline in body weight near the end of life) than with chronological age per je. Together with our previous findings, the current observations are consistent with the hypothesis that the transition from gradual aging to senescence reflects altered hypothalamic regulation. (Supported by NIH Grant AG06665 and NASA Grant NAG2-944).

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - 1996

Fingerprint

Circadian Rhythm
Body Temperature
circadian rhythm
body temperature
Rats
Weight Loss
weight loss
Aging of materials
Body Weight
body weight
rats
Temperature
Inbred F344 Rats
United States National Aeronautics and Space Administration
temperature
Radio Waves
radio waves
Induced Hypothermia
hypothalamic regulation
Abdominal Cavity

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

McDonald, R. B., Murtagh-Mark, C. M., Fuller, C. A., Hoban-Higgins, T. M., & Horwitz, B. A. (1996). Relationship between circadian rhythm of body temperature and weight loss in aging rats. FASEB Journal, 10(3).

Relationship between circadian rhythm of body temperature and weight loss in aging rats. / McDonald, R. B.; Murtagh-Mark, C. M.; Fuller, C. A.; Hoban-Higgins, T. M.; Horwitz, Barbara A.

In: FASEB Journal, Vol. 10, No. 3, 1996.

Research output: Contribution to journalArticle

McDonald, RB, Murtagh-Mark, CM, Fuller, CA, Hoban-Higgins, TM & Horwitz, BA 1996, 'Relationship between circadian rhythm of body temperature and weight loss in aging rats', FASEB Journal, vol. 10, no. 3.
McDonald RB, Murtagh-Mark CM, Fuller CA, Hoban-Higgins TM, Horwitz BA. Relationship between circadian rhythm of body temperature and weight loss in aging rats. FASEB Journal. 1996;10(3).
McDonald, R. B. ; Murtagh-Mark, C. M. ; Fuller, C. A. ; Hoban-Higgins, T. M. ; Horwitz, Barbara A. / Relationship between circadian rhythm of body temperature and weight loss in aging rats. In: FASEB Journal. 1996 ; Vol. 10, No. 3.
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