Relation of calcium, vitamin d, and dairy food intake to incidence of colon cancer among older women: The iowa women's health study

Roberd M. Bostick, John D. Potter, Thomas A. Sellers, David R. Mckenzie, Lawrence H. Kushi, Aaron R. Folsom

Research output: Contribution to journalArticle

229 Citations (Scopus)

Abstract

To investigate whether a high intake of calcium, vitamin D, or dairy products may protect against colon cancer, the authors analyzed data from a prospective cohort study of 35,216 Iowa women aged 55-69 years without a history of cancer who completed a dietary questionnaire in 1986. Through 1990, 212 incident cases of colon cancer were documented. Adjusted for age, intakes of calcium and vitamin D were significantly inversely associated with the risk of colon cancer. The relative risks for the highest quintile of intake as compared with the lowest were 0.52 (95% confidence interval (CI) 0.33-0.82) for calcium and 0.54 (95% CI 0.35-0.84) for vitamin D. After multivariate adjustment, the trends were no longer statistically significant and the relative risks for the highest versus the lowest quintiles of calcium and vitamin D intakes were attenuated: 0.68 (95% CI 0.41-1.11) for calcium and 0.73 (95% CI 0.45-1.18) for vitamin D. Although the multivariate-adjusted findings did not reach statistical significance at p ≤ 0.05, when considered in the context of the whole body of literature on this subject, they are consistent with a possible role for calcium or vitamin D in modestly reducing colon cancer risk.

Original languageEnglish (US)
Pages (from-to)1302-1317
Number of pages16
JournalAmerican Journal of Epidemiology
Volume137
Issue number12
StatePublished - Jun 15 1993
Externally publishedYes

Fingerprint

Women's Health
Vitamin D
Vitamins
Colonic Neoplasms
Eating
Calcium
Incidence
Confidence Intervals
Dairy Products
Cohort Studies
Prospective Studies
Neoplasms

Keywords

  • Calcium, dietary
  • Colonic neoplasms
  • Dairy products
  • Prospective studies
  • Vitamin D

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Epidemiology

Cite this

Bostick, R. M., Potter, J. D., Sellers, T. A., Mckenzie, D. R., Kushi, L. H., & Folsom, A. R. (1993). Relation of calcium, vitamin d, and dairy food intake to incidence of colon cancer among older women: The iowa women's health study. American Journal of Epidemiology, 137(12), 1302-1317.

Relation of calcium, vitamin d, and dairy food intake to incidence of colon cancer among older women : The iowa women's health study. / Bostick, Roberd M.; Potter, John D.; Sellers, Thomas A.; Mckenzie, David R.; Kushi, Lawrence H.; Folsom, Aaron R.

In: American Journal of Epidemiology, Vol. 137, No. 12, 15.06.1993, p. 1302-1317.

Research output: Contribution to journalArticle

Bostick, RM, Potter, JD, Sellers, TA, Mckenzie, DR, Kushi, LH & Folsom, AR 1993, 'Relation of calcium, vitamin d, and dairy food intake to incidence of colon cancer among older women: The iowa women's health study', American Journal of Epidemiology, vol. 137, no. 12, pp. 1302-1317.
Bostick, Roberd M. ; Potter, John D. ; Sellers, Thomas A. ; Mckenzie, David R. ; Kushi, Lawrence H. ; Folsom, Aaron R. / Relation of calcium, vitamin d, and dairy food intake to incidence of colon cancer among older women : The iowa women's health study. In: American Journal of Epidemiology. 1993 ; Vol. 137, No. 12. pp. 1302-1317.
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