Rejection of bone marrow cells by irradiation mice: NK and T cells recognize different antigens

M. Bennett, V. Kumar, A. Mikhael, William J Murphy, R. M. Rembecki, C. L. Sentman, C. S. David

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Numerous studies have indicated that rejection of bone marrow cell (BML) grafts by lethally irradiated mice can be attributed to either NK cells or radioresistent T cells. The four hypotheses that could explain the medianism(s) of rejection of BMC grafts by NK cells include: (1) Donor marrow cells recognize alloantigens of the host and activate host NK cells to attack donor stem cells, the 'allogeneic inhibition' concept; (2) NK cells lyse stem cells coated with natural antibodies via ADCC using their Fc receptors for IgG; (3) NK cells survey the cell surface of stem cells for self H-2 antigens and look or decrease of self H-2 triggers killing; and (4) NK cells recognize with specific receptors H-2 linked hemopoietic histocompatibility (Hh) antigens. The date reviewed on this paper let us to conclude that the mechanism of rejection of BMC allografts by NK involves the use of unique receptors of Hh antigens coded for by genes which map to the S/D interval of H-2 and which are not class I determinants. Furthermore radioresistant Lyt-2+ T cells recognize H-2 antigen (class I) on H-2 homozygous or heterozygous BMC. In contrast to NK cells which reject BMC allografts after 24 hours T cells can be stimulated to reject BMC graft by day 7 or 8 after immunization. A model for acute rejction of BMC grafts by NK and T cells is presented.

Original languageEnglish (US)
Pages (from-to)5-11
Number of pages7
JournalTransplantation Proceedings
Volume19
Issue number6 SUPPL. 7
StatePublished - 1987
Externally publishedYes

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Natural Killer Cells
Bone Marrow Cells
T-Lymphocytes
Antigens
H-2 Antigens
Histocompatibility Antigens
Stem Cells
Transplants
Allografts
Antibody-Dependent Cell Cytotoxicity
Isoantigens
Fc Receptors
Graft Rejection
Immunization
Immunoglobulin G
Bone Marrow
Antibodies
Genes

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Bennett, M., Kumar, V., Mikhael, A., Murphy, W. J., Rembecki, R. M., Sentman, C. L., & David, C. S. (1987). Rejection of bone marrow cells by irradiation mice: NK and T cells recognize different antigens. Transplantation Proceedings, 19(6 SUPPL. 7), 5-11.

Rejection of bone marrow cells by irradiation mice : NK and T cells recognize different antigens. / Bennett, M.; Kumar, V.; Mikhael, A.; Murphy, William J; Rembecki, R. M.; Sentman, C. L.; David, C. S.

In: Transplantation Proceedings, Vol. 19, No. 6 SUPPL. 7, 1987, p. 5-11.

Research output: Contribution to journalArticle

Bennett, M, Kumar, V, Mikhael, A, Murphy, WJ, Rembecki, RM, Sentman, CL & David, CS 1987, 'Rejection of bone marrow cells by irradiation mice: NK and T cells recognize different antigens', Transplantation Proceedings, vol. 19, no. 6 SUPPL. 7, pp. 5-11.
Bennett M, Kumar V, Mikhael A, Murphy WJ, Rembecki RM, Sentman CL et al. Rejection of bone marrow cells by irradiation mice: NK and T cells recognize different antigens. Transplantation Proceedings. 1987;19(6 SUPPL. 7):5-11.
Bennett, M. ; Kumar, V. ; Mikhael, A. ; Murphy, William J ; Rembecki, R. M. ; Sentman, C. L. ; David, C. S. / Rejection of bone marrow cells by irradiation mice : NK and T cells recognize different antigens. In: Transplantation Proceedings. 1987 ; Vol. 19, No. 6 SUPPL. 7. pp. 5-11.
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