Rejection of bone marrow allografts by mice with severe combined immune deficiency (SCID). Evidence that natural killer cells can mediate the specificity of marrow graft rejection

William J Murphy, V. Kumar, M. Bennett

Research output: Contribution to journalArticle

217 Scopus citations

Abstract

C.B-17 scid (H-2(d)) mice are homozygous for the gene that causes severe combined immune deficiency (SCID). These mice have no T or B cell function, yet display normal natural killer (NK) activity. Irradiated SCID mice were challenged with marrow grafts to determine if antibodies are necessary for marrow allograft rejection. SCID mice rejected H-2/Hh-1 allogeneic marrow grafts. Moreover, this rejection capability could be adoptively transferred using SCID marrow as a source of NK progenitors infused into irradiated B6 (H-2b) hosts. We conclude that NK cells can mediate marrow allograft reactivity in the absence of immunoglobulin. It follows that NK cells probably have specific receptors for Hh antigens.

Original languageEnglish (US)
Pages (from-to)1212-1217
Number of pages6
JournalJournal of Experimental Medicine
Volume165
Issue number4
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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