Reirradiation of tumors in cats and dogs.

J. M. Turrel, Alain P Theon

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Fifty-one cats and dogs with tumor recurrence after irradiation were treated with a second course of radiotherapy, using either teletherapy or brachytherapy. Eighty-six percent of the tumors had partial or complete response at 2 months after reirradiation. Tumor response was significantly (P = 0.041) affected when the interval between the 2 courses of irradiation was greater than 5 months. The estimated local tumor control rate was 38% at 1 year after reirradiation. Of all the factors examined, complete response at 2 months, reirradiation field size less than or equal to 10 cm2, and reirradiation dose greater than 40 gray emerged as predictors of local tumor control. The estimated overall survival rate was 47% at 2 years. Tumor location had a significant (P = 0.001) influence on overall survival; animals with cutaneous tumors had the longest survival times, and those with oral tumors had the shortest survival times. The other significant (P = 0.001) factor affecting overall survival time was the field size of the reirradiated site. Estimated survival time after reirradiation was 41% at 1 year. Favorable prognostic indicators were complete response at 2 months and location of tumor; animals with skin tumors had a favorable prognosis. The acute effects of reirradiation on normal tissues were acceptable, but 12% of the animals had severe delayed complications. Significant risk of complications after reirradiation was associated with squamous cell carcinoma (P = 0.015) and reirradiated field size greater than 30 cm2 (P = 0.056). When the interval between irradiations was greater than 5 months, the risk of complications was significantly (P = 0.022) lower.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish (US)
Pages (from-to)465-469
Number of pages5
JournalJournal of the American Veterinary Medical Association
Volume193
Issue number4
StatePublished - Aug 15 1988

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Cats
Dogs
cats
neoplasms
dogs
Neoplasms
irradiation
Re-Irradiation
animals
Skin
acute effects
squamous cell carcinoma
radiotherapy
Brachytherapy
prognosis
mouth
Squamous Cell Carcinoma
survival rate
Radiotherapy
Recurrence

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Reirradiation of tumors in cats and dogs. / Turrel, J. M.; Theon, Alain P.

In: Journal of the American Veterinary Medical Association, Vol. 193, No. 4, 15.08.1988, p. 465-469.

Research output: Contribution to journalArticle

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