Reinnervation of laryngeal muscles: A study of changes in myosin heavy chain expression

Paul J. Kingham, Martin A. Birchall, Rachel Burt, Alan Jones, Giorgio Terenghi

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Direct repair of the recurrent laryngeal nerve (RLN) results in synkinesis and compromised laryngeal function. We have therefore developed a pig model to investigate whether anastomosis of the phrenic nerve with the abductor branch of the RLN leads to specific reinnervation of abductor muscles. Expression of myosin heavy chain protein (MyHC), a marker of appropriate reinnervation, was determined in the posterior cricoarytenoid (PCA) abductor and thyroarytenoid (TA) adductor muscles following nerve injury and repair. The denervated PCA muscle exhibited decreased levels of the fast-type MyHC isoforms IIA and IIB, and increased slow-type MyHC expression. Similarly, there was a fall in type IIB levels in the denervated TA muscle but increases in both IIA and slow MyHC. Four months after repair, the MyHC expression in the PCA was near normal, suggesting that our model reduces the risk of synkinesis and ensures the accurate muscle reinnervation required for full functional recovery.

Original languageEnglish (US)
Pages (from-to)761-766
Number of pages6
JournalMuscle and Nerve
Issue number6
StatePublished - Dec 2005
Externally publishedYes


  • Denervation
  • Larynx
  • Recurrent laryngeal nerve
  • Synkinesis
  • Transplantation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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