Regulation of voltage-gated potassium channels in vascular smooth muscle during hypertension and metabolic disorders

Madeline Nieves-Cintrón, Arsalan U. Syed, Matthew A. Nystoriak, Manuel F. Navedo

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Voltage-gated potassium (KV) channels are key regulators of vascular smooth muscle contractility and vascular tone, and thus have major influence on the microcirculation. KV channels are important determinants of vascular smooth muscle membrane potential (Em). A number of KV subunits are expressed in the plasma membrane of smooth muscle cells. Each subunit confers distinct kinetics and regulatory properties that allow for fine control of Em to orchestrate vascular tone. Modifications in KV subunit expression and/or channel activity can contribute to changes in vascular smooth muscle contractility in response to different stimuli and in diverse pathological conditions. Consistent with this, a number of studies suggest alterations in KV subunit expression and/or function as underlying contributing mechanisms for small resistance artery dysfunction in pathologies such as hypertension and metabolic disorders, including diabetes. Here, we review our current knowledge on the effects of these pathologies on KV channel expression and function in vascular smooth muscle cells, and the repercussions on (micro)vascular function.

Original languageEnglish (US)
Article numbere12423
JournalMicrocirculation
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2018

Keywords

  • ion channels
  • microcirculation
  • signal transduction
  • vascular dysfunction

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Regulation of voltage-gated potassium channels in vascular smooth muscle during hypertension and metabolic disorders'. Together they form a unique fingerprint.

  • Cite this