Regulation of the p53 transcriptional activity

Gang Liu, Xinbin Chen

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

In response to various stresses, p53 is rapidly activated and transcriptionally regulates a number of target genes by which p53 modulates a variety of cellular activities. The transcriptional activity of p53 is delicately regulated by a plethora of cellular factors, independently or synergistically, in multiple ways in order to achieve a specific response. This article reviewed the role of the basal transcriptional machinery, co-activators, and co-repressors involved in p53-dependent transcription, and the underlying mechanism by which the p53 transcriptional activity is regulated. We also discussed some potentially interesting questions and future directions in the field.

Original languageEnglish (US)
Pages (from-to)448-458
Number of pages11
JournalJournal of Cellular Biochemistry
Volume97
Issue number3
DOIs
StatePublished - Feb 15 2006
Externally publishedYes

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Keywords

  • Basal transcriptional machinery
  • Co-activator
  • Co-repressor
  • p53
  • Post-translational modification
  • Transcription

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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