Abstract
In response to various stresses, p53 is rapidly activated and transcriptionally regulates a number of target genes by which p53 modulates a variety of cellular activities. The transcriptional activity of p53 is delicately regulated by a plethora of cellular factors, independently or synergistically, in multiple ways in order to achieve a specific response. This article reviewed the role of the basal transcriptional machinery, co-activators, and co-repressors involved in p53-dependent transcription, and the underlying mechanism by which the p53 transcriptional activity is regulated. We also discussed some potentially interesting questions and future directions in the field.
Original language | English (US) |
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Pages (from-to) | 448-458 |
Number of pages | 11 |
Journal | Journal of Cellular Biochemistry |
Volume | 97 |
Issue number | 3 |
DOIs | |
State | Published - Feb 15 2006 |
Externally published | Yes |
Keywords
- Basal transcriptional machinery
- Co-activator
- Co-repressor
- p53
- Post-translational modification
- Transcription
ASJC Scopus subject areas
- Biochemistry
- Cell Biology