Regulation of the major proline permease gene of Salmonella typhimurium

B. Ratzkin, M. Grabnar, J. Roth

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


The structural gene for the major proline permease is located in a tight cluster with genes coding for the proline degradative enzymes, proline oxidase and pyrroline-5-carboxylic acid dehydrogenase. Expression of the permease is regulated in parallel with the two degradative enzymes, and all three functions are subject to catabolite repression. Regulatory mutants (putC) have constitutively high levels of all three activities, suggesting that all are regulated by a single mechanism.

Original languageEnglish (US)
Pages (from-to)737-743
Number of pages7
JournalJournal of Bacteriology
Issue number2
StatePublished - 1978

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology


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