Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells

Andrew W. Taylor-Robinson, Foo Y. Liew, Alison Severn, Damo Xu, Stephen J Mcsorley, Paul Garside, Julio Padron, R. Stephen Phillips

Research output: Contribution to journalArticle

347 Citations (Scopus)

Abstract

The balance between T helper type 1 (Th1) and T helper type 2 (Th2) cells determines the outcome of many important diseases. Using cloned murine T cell lines, evidence is provided that Th1, but not Th2, cells can be activated by specific antigens or a T cell mitogen, concanavalin A, to produce large amounts of nitric oxide (NO). Furthermore, NO can inhibit the secretion of interleukin (IL)-2 and interferon-γ by Th1 cells but has no effect on IL-4 production by Th2 cells. Th1 and Th2 cells can, thus, be distinguished by their differential production of and susceptibility to NO. NO exerts a self-regulatory effect on Th1 cells which are implicated in immunopathology.

Original languageEnglish (US)
Pages (from-to)980-984
Number of pages5
JournalEuropean Journal of Immunology
Volume24
Issue number4
StatePublished - Apr 1994
Externally publishedYes

Fingerprint

Th1 Cells
Nitric Oxide
Th2 Cells
T-Lymphocytes
Concanavalin A
Mitogens
Interleukin-4
Interferons
Interleukin-2
Antigens
Cell Line

Keywords

  • Nitric oxide
  • Th1
  • Th2

ASJC Scopus subject areas

  • Immunology

Cite this

Taylor-Robinson, A. W., Liew, F. Y., Severn, A., Xu, D., Mcsorley, S. J., Garside, P., ... Phillips, R. S. (1994). Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells. European Journal of Immunology, 24(4), 980-984.

Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells. / Taylor-Robinson, Andrew W.; Liew, Foo Y.; Severn, Alison; Xu, Damo; Mcsorley, Stephen J; Garside, Paul; Padron, Julio; Phillips, R. Stephen.

In: European Journal of Immunology, Vol. 24, No. 4, 04.1994, p. 980-984.

Research output: Contribution to journalArticle

Taylor-Robinson, AW, Liew, FY, Severn, A, Xu, D, Mcsorley, SJ, Garside, P, Padron, J & Phillips, RS 1994, 'Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells', European Journal of Immunology, vol. 24, no. 4, pp. 980-984.
Taylor-Robinson, Andrew W. ; Liew, Foo Y. ; Severn, Alison ; Xu, Damo ; Mcsorley, Stephen J ; Garside, Paul ; Padron, Julio ; Phillips, R. Stephen. / Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells. In: European Journal of Immunology. 1994 ; Vol. 24, No. 4. pp. 980-984.
@article{13b9707bafe34d46ab8dba0d432584fb,
title = "Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells",
abstract = "The balance between T helper type 1 (Th1) and T helper type 2 (Th2) cells determines the outcome of many important diseases. Using cloned murine T cell lines, evidence is provided that Th1, but not Th2, cells can be activated by specific antigens or a T cell mitogen, concanavalin A, to produce large amounts of nitric oxide (NO). Furthermore, NO can inhibit the secretion of interleukin (IL)-2 and interferon-γ by Th1 cells but has no effect on IL-4 production by Th2 cells. Th1 and Th2 cells can, thus, be distinguished by their differential production of and susceptibility to NO. NO exerts a self-regulatory effect on Th1 cells which are implicated in immunopathology.",
keywords = "Nitric oxide, Th1, Th2",
author = "Taylor-Robinson, {Andrew W.} and Liew, {Foo Y.} and Alison Severn and Damo Xu and Mcsorley, {Stephen J} and Paul Garside and Julio Padron and Phillips, {R. Stephen}",
year = "1994",
month = "4",
language = "English (US)",
volume = "24",
pages = "980--984",
journal = "European Journal of Immunology",
issn = "0014-2980",
publisher = "Wiley-VCH Verlag",
number = "4",

}

TY - JOUR

T1 - Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells

AU - Taylor-Robinson, Andrew W.

AU - Liew, Foo Y.

AU - Severn, Alison

AU - Xu, Damo

AU - Mcsorley, Stephen J

AU - Garside, Paul

AU - Padron, Julio

AU - Phillips, R. Stephen

PY - 1994/4

Y1 - 1994/4

N2 - The balance between T helper type 1 (Th1) and T helper type 2 (Th2) cells determines the outcome of many important diseases. Using cloned murine T cell lines, evidence is provided that Th1, but not Th2, cells can be activated by specific antigens or a T cell mitogen, concanavalin A, to produce large amounts of nitric oxide (NO). Furthermore, NO can inhibit the secretion of interleukin (IL)-2 and interferon-γ by Th1 cells but has no effect on IL-4 production by Th2 cells. Th1 and Th2 cells can, thus, be distinguished by their differential production of and susceptibility to NO. NO exerts a self-regulatory effect on Th1 cells which are implicated in immunopathology.

AB - The balance between T helper type 1 (Th1) and T helper type 2 (Th2) cells determines the outcome of many important diseases. Using cloned murine T cell lines, evidence is provided that Th1, but not Th2, cells can be activated by specific antigens or a T cell mitogen, concanavalin A, to produce large amounts of nitric oxide (NO). Furthermore, NO can inhibit the secretion of interleukin (IL)-2 and interferon-γ by Th1 cells but has no effect on IL-4 production by Th2 cells. Th1 and Th2 cells can, thus, be distinguished by their differential production of and susceptibility to NO. NO exerts a self-regulatory effect on Th1 cells which are implicated in immunopathology.

KW - Nitric oxide

KW - Th1

KW - Th2

UR - http://www.scopus.com/inward/record.url?scp=0028328352&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028328352&partnerID=8YFLogxK

M3 - Article

C2 - 8149966

AN - SCOPUS:0028328352

VL - 24

SP - 980

EP - 984

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

IS - 4

ER -