Regulation of the genes for proline utilization in Salmonella typhimurium: Autogenous repression by the putA gene product

Rolf Menzel, John Roth

Research output: Contribution to journalArticle

52 Scopus citations


Two genes are involved in the degradation of proline to glutamic acid. The putP gene encodes a proline permease; the putA gene encodes a bifunctional degradative enzyme. Although the two genes are transcribed independently, both genes are induced by exogenous proline and are subject to catabolite repression. The putA gene product appears to function also as an autogenous repressor protein acting on both the putA and putP transcription units. Regulatory mutations map throughout the putA gene; these are correctable by an episomal putA+ gene, which acts in trans to restore repression.

Original languageEnglish (US)
Pages (from-to)21-44
Number of pages24
JournalJournal of Molecular Biology
Issue number1
StatePublished - May 5 1981
Externally publishedYes


ASJC Scopus subject areas

  • Virology

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