Regulation of the depth and composition of airway surface liquid

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

The airways are lined with a film of liquid about 10 μm deep that is in two layers. Around the cilia is the watery perciliary sol. Over this is a mucous blanket that traps inhaled particles. The low viscosity of the periciliary sol allows the cilia to beat and propel the mucous blanket to the mouth. In large airways, mucus comes predominantly from the mucous glands but also from goblet cells in the surface epithelium. Water is added to the airway surface by gland secretion that is driven by active Cl secretion by serous cells. During inflammation elevation of the sub-epithelial hydrostatic pressure may also add significant volumes of water to the airway lumen. Water is removed by active Na transport across the surface epithelium. In airway diseases, the balance is shifted from water secretion to mucus secretion. In bronchitis and asthma this is due mainly to conversion of gland serous to mucous cells. In cystic fibrosis, gland serous cells cannot secrete water because they lack functioning CFTR in their apical membranes (CFTR is the cystic fibrosis transmembrane conductance regulator, a Cl channel that is abundant in serous cells). In all three diseases, the result is secretion of excessively concentrated gland secretions that are poorly moved by the cilia and accumulate. Altered salt and water transport by the surface epithelium may also contribute to the pathology of cystic fibrosis.

Original languageEnglish (US)
Pages (from-to)313-318
Number of pages6
JournalJournal of Anatomy
Volume201
Issue number4
DOIs
StatePublished - Oct 1 2002

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secretion
liquid
liquids
Water
Cilia
cystic fibrosis
cilia
Epithelium
water
mucus
Polymethyl Methacrylate
Mucus
epithelium
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
cells
Hydrostatic Pressure
Goblet Cells
Bronchitis
Active Biological Transport

Keywords

  • Airway epithelium
  • Cystic fibrosis
  • Mucous secretions

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Anatomy

Cite this

Regulation of the depth and composition of airway surface liquid. / Widdicombe, Jonathan.

In: Journal of Anatomy, Vol. 201, No. 4, 01.10.2002, p. 313-318.

Research output: Contribution to journalArticle

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