Abstract
Tenascins regulate cell interaction with the surrounding pericellular matrix. Within bone, tenascins C and W influence osteoblast adhesion and differentiation, although little is known about the regulation of tenascin expression. In this study we examined the effect of osteogenic differentiation, bone morphogenetic protein (BMP) and Wnt growth factors, and mechanical loading on tenascin expression in osteogenic cells. Osteogenic differentiation increased tenascin C (TnC), and decreased tenascin W (TnW), expression. Both growth factors and mechanical loading increased both TnC and TnW expression, albeit via distinct signaling mechanisms. Both BMP-2 and Wnt5a induction of tenascin expression were mediated by MAP kinases. These data establish a role for BMP, Wnts, and mechanical loading in the regulation of tenascin expression in osteoblasts.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3354-3363 |
| Number of pages | 10 |
| Journal | Journal of Cellular Biochemistry |
| Volume | 112 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2011 |
Fingerprint
Keywords
- bone morphogenetic protein
- MAPK
- mechanotransduction
- osteoblast
- osteocyte
- tenascin
- Wnt
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology
Cite this
Regulation of tenascin expression in bone. / Morgan, Jessica M.; Wong, Alice; Yellowley-genetos, Clare E; Genetos, Damian C.
In: Journal of Cellular Biochemistry, Vol. 112, No. 11, 11.2011, p. 3354-3363.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of tenascin expression in bone
AU - Morgan, Jessica M.
AU - Wong, Alice
AU - Yellowley-genetos, Clare E
AU - Genetos, Damian C
PY - 2011/11
Y1 - 2011/11
N2 - Tenascins regulate cell interaction with the surrounding pericellular matrix. Within bone, tenascins C and W influence osteoblast adhesion and differentiation, although little is known about the regulation of tenascin expression. In this study we examined the effect of osteogenic differentiation, bone morphogenetic protein (BMP) and Wnt growth factors, and mechanical loading on tenascin expression in osteogenic cells. Osteogenic differentiation increased tenascin C (TnC), and decreased tenascin W (TnW), expression. Both growth factors and mechanical loading increased both TnC and TnW expression, albeit via distinct signaling mechanisms. Both BMP-2 and Wnt5a induction of tenascin expression were mediated by MAP kinases. These data establish a role for BMP, Wnts, and mechanical loading in the regulation of tenascin expression in osteoblasts.
AB - Tenascins regulate cell interaction with the surrounding pericellular matrix. Within bone, tenascins C and W influence osteoblast adhesion and differentiation, although little is known about the regulation of tenascin expression. In this study we examined the effect of osteogenic differentiation, bone morphogenetic protein (BMP) and Wnt growth factors, and mechanical loading on tenascin expression in osteogenic cells. Osteogenic differentiation increased tenascin C (TnC), and decreased tenascin W (TnW), expression. Both growth factors and mechanical loading increased both TnC and TnW expression, albeit via distinct signaling mechanisms. Both BMP-2 and Wnt5a induction of tenascin expression were mediated by MAP kinases. These data establish a role for BMP, Wnts, and mechanical loading in the regulation of tenascin expression in osteoblasts.
KW - bone morphogenetic protein
KW - MAPK
KW - mechanotransduction
KW - osteoblast
KW - osteocyte
KW - tenascin
KW - Wnt
UR - http://www.scopus.com/inward/record.url?scp=80054968751&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80054968751&partnerID=8YFLogxK
U2 - 10.1002/jcb.23265
DO - 10.1002/jcb.23265
M3 - Article
C2 - 21751239
AN - SCOPUS:80054968751
VL - 112
SP - 3354
EP - 3363
JO - Journal of Cellular Biochemistry
JF - Journal of Cellular Biochemistry
SN - 0730-2312
IS - 11
ER -