Abstract
Steroidogenesis involves the conversion of cholesterol to glucocorticoids, mineralocorticoids, and sex steroids, which regulate development and physiology. Steroidogenesis is often discussed in a gland-specific fashion, but is better understood as a single process that is repeated in each gland with cell type-specific variations. Thus, the regulation of steroidogenesis occurs by regulating the transcription and post-translational modification of the steroidogenic enzymes and co-factors, in a tissue-specific fashion. Most steroidogenic enzymes are either hydroxysteroid dehydrogenases or cytochrome P450 enzymes; the activities of these enzymes are modulated by post-translational modifications and co-factors, especially electron-donating redox partners. The first and rate-limiting steroidogenic step is catalyzed by P450scc in all steroidogenic tissues, determining steroidogenic capacity; the qualitative regulation of steroidogenesis determining the class of steroid produced is principally mediated by P450c17. Understanding steroidogenesis permits understanding disorders of sexual differentiation, reproduction, fertility, hypertension, obesity, and physiologic homeostasis, and is essential for rational steroid therapies.
| Original language | English (US) |
|---|---|
| Title of host publication | Cellular Endocrinology in Health and Disease |
| Publisher | Elsevier Inc. |
| Pages | 207-227 |
| Number of pages | 21 |
| ISBN (Print) | 9780124081345 |
| DOIs | |
| State | Published - May 2014 |
| Externally published | Yes |
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Keywords
- Adrenal
- Adrenarche
- Androgens
- Estrogens
- Glucocorticoid
- Gonad
- Mineralocorticoid
- Steroid
- Steroidogenesis
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Regulation of Steroidogenesis. / Bremer, Andrew A.; Miller, Walter L.
Cellular Endocrinology in Health and Disease. Elsevier Inc., 2014. p. 207-227.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Regulation of Steroidogenesis
AU - Bremer, Andrew A.
AU - Miller, Walter L.
PY - 2014/5
Y1 - 2014/5
N2 - Steroidogenesis involves the conversion of cholesterol to glucocorticoids, mineralocorticoids, and sex steroids, which regulate development and physiology. Steroidogenesis is often discussed in a gland-specific fashion, but is better understood as a single process that is repeated in each gland with cell type-specific variations. Thus, the regulation of steroidogenesis occurs by regulating the transcription and post-translational modification of the steroidogenic enzymes and co-factors, in a tissue-specific fashion. Most steroidogenic enzymes are either hydroxysteroid dehydrogenases or cytochrome P450 enzymes; the activities of these enzymes are modulated by post-translational modifications and co-factors, especially electron-donating redox partners. The first and rate-limiting steroidogenic step is catalyzed by P450scc in all steroidogenic tissues, determining steroidogenic capacity; the qualitative regulation of steroidogenesis determining the class of steroid produced is principally mediated by P450c17. Understanding steroidogenesis permits understanding disorders of sexual differentiation, reproduction, fertility, hypertension, obesity, and physiologic homeostasis, and is essential for rational steroid therapies.
AB - Steroidogenesis involves the conversion of cholesterol to glucocorticoids, mineralocorticoids, and sex steroids, which regulate development and physiology. Steroidogenesis is often discussed in a gland-specific fashion, but is better understood as a single process that is repeated in each gland with cell type-specific variations. Thus, the regulation of steroidogenesis occurs by regulating the transcription and post-translational modification of the steroidogenic enzymes and co-factors, in a tissue-specific fashion. Most steroidogenic enzymes are either hydroxysteroid dehydrogenases or cytochrome P450 enzymes; the activities of these enzymes are modulated by post-translational modifications and co-factors, especially electron-donating redox partners. The first and rate-limiting steroidogenic step is catalyzed by P450scc in all steroidogenic tissues, determining steroidogenic capacity; the qualitative regulation of steroidogenesis determining the class of steroid produced is principally mediated by P450c17. Understanding steroidogenesis permits understanding disorders of sexual differentiation, reproduction, fertility, hypertension, obesity, and physiologic homeostasis, and is essential for rational steroid therapies.
KW - Adrenal
KW - Adrenarche
KW - Androgens
KW - Estrogens
KW - Glucocorticoid
KW - Gonad
KW - Mineralocorticoid
KW - Steroid
KW - Steroidogenesis
UR - http://www.scopus.com/inward/record.url?scp=84902390571&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902390571&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-408134-5.00013-5
DO - 10.1016/B978-0-12-408134-5.00013-5
M3 - Chapter
SN - 9780124081345
SP - 207
EP - 227
BT - Cellular Endocrinology in Health and Disease
PB - Elsevier Inc.
ER -