Regulation of recombination and genomic maintenance

Wolf Dietrich Heyer

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Recombination is a central process to stably maintain and transmit a genome through somatic cell divisions and to new generations. Hence, recombination needs to be coordinated with other events occurring on the DNA template, such as DNA replication, transcription, and the specialized chromosomal functions at centromeres and telomeres. Moreover, regulation with respect to the cell-cycle stage is required as much as spatiotemporal coordination within the nuclear volume. These regulatory mechanisms impinge on the DNA substrate through modifications of the chromatin and directly on recombination proteins through a myriad of posttranslational modifications (PTMs) and additional mechanisms. Although recombination is primarily appreciated to maintain genomic stability, the process also contributes to gross chromosomal arrangements and copy-number changes. Hence, the recombination process itself requires quality control to ensure high fidelity and avoid genomic instability. Evidently, recombination and its regulatory processes have significant impact on human disease, specifically cancer and, possibly, neurodegenerative diseases.

Original languageEnglish (US)
JournalCold Spring Harbor perspectives in biology
Volume7
Issue number8
DOIs
StatePublished - Aug 1 2015

Fingerprint

Genetic Recombination
Maintenance
DNA
Cells
Neurodegenerative diseases
Genomic Instability
Transcription
Chromatin
Quality control
Genes
Centromere
Telomere
Substrates
Post Translational Protein Processing
DNA Replication
Neurodegenerative Diseases
Quality Control
Cell Division
Cell Cycle
Proteins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Regulation of recombination and genomic maintenance. / Heyer, Wolf Dietrich.

In: Cold Spring Harbor perspectives in biology, Vol. 7, No. 8, 01.08.2015.

Research output: Contribution to journalArticle

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