Abstract
The regenerative potential of the vertebrate skeletal system is well known. Normal cartilage and bone development can be mimicked by implantation of demineralized bone matrix, which induces bone formation locally. The sequential stages of the matrix-induced bone development and recent advances in the underlying biochemical mechanisms are described. The extracellular matrix components have chemotactic, mitogenic and differentiative activities. It would appear that a cascade type mechanism is operative during local differentiation of endochondral bone.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 261-268 |
| Number of pages | 8 |
| Journal | Progress in Clinical and Biological Research |
| Volume | 110 Pt B |
| State | Published - 1982 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Regulation of local differentiation of cartilage and bone by extracellular matrix : a cascade type mechanism. / Reddi, A Hari.
In: Progress in Clinical and Biological Research, Vol. 110 Pt B, 1982, p. 261-268.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of local differentiation of cartilage and bone by extracellular matrix
T2 - a cascade type mechanism.
AU - Reddi, A Hari
PY - 1982
Y1 - 1982
N2 - The regenerative potential of the vertebrate skeletal system is well known. Normal cartilage and bone development can be mimicked by implantation of demineralized bone matrix, which induces bone formation locally. The sequential stages of the matrix-induced bone development and recent advances in the underlying biochemical mechanisms are described. The extracellular matrix components have chemotactic, mitogenic and differentiative activities. It would appear that a cascade type mechanism is operative during local differentiation of endochondral bone.
AB - The regenerative potential of the vertebrate skeletal system is well known. Normal cartilage and bone development can be mimicked by implantation of demineralized bone matrix, which induces bone formation locally. The sequential stages of the matrix-induced bone development and recent advances in the underlying biochemical mechanisms are described. The extracellular matrix components have chemotactic, mitogenic and differentiative activities. It would appear that a cascade type mechanism is operative during local differentiation of endochondral bone.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020390284&partnerID=8YFLogxK
M3 - Article
VL - 110 Pt B
SP - 261
EP - 268
JO - Progress in Clinical and Biological Research
JF - Progress in Clinical and Biological Research
SN - 0361-7742
ER -