Regulation of ion channel expression by cytoplasmic subunits

James Trimmer

Research output: Contribution to journalArticle

92 Scopus citations

Abstract

Neuronal and cardiac voltage-gated ion channels contain auxiliary subunits that can profoundly affect the gating of the pore-forming and voltage-sensing α subunits. Recent studies on the structurally similar cytoplasmic β subunits of Ca2+ and K+ channels reveal that these subunits can also exert profound effects on the expression of the integral membrane protein channel components. The mechanisms by which these effects occur are now being elucidated through a combined approach that employs biophysical, pharmacological, cell biological and biochemical techniques.

Original languageEnglish (US)
Pages (from-to)370-374
Number of pages5
JournalCurrent Opinion in Neurobiology
Volume8
Issue number3
DOIs
StatePublished - Jun 1998
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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