The authors are investigating the mechanisms whereby endothelial cells modulate the permeability of microvessels to macro-molecules. After application of histamine and bradykinin to postcapillary venules in the mammalian microvasculature, gaps (ranging in size from 0. 1 to 1 mu m) have been reported within localized leaky sites. To investigate the quantitative relations between localized increases in permeability and changes in junction geometry, apparent solute permeability coefficients, in short segments of individually perfused microvessels in frog and hamster mesentery and hamster cheek pouch were measured at a series of capillary pressures in each vessel.
|Original language||English (US)|
|Title of host publication||American Society of Mechanical Engineers, Bioengineering Division (Publication) BED|
|Place of Publication||New York, NY, USA|
|Publisher||ASME (DE v 12)|
|Number of pages||1|
|State||Published - 1987|
ASJC Scopus subject areas