REGULATION OF ENDOTHELIAL PERMEABILITY IN SINGLE PERFUSED CAPILLARIES.

Fitz Roy E Curry, William L. Joyner

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The authors are investigating the mechanisms whereby endothelial cells modulate the permeability of microvessels to macro-molecules. After application of histamine and bradykinin to postcapillary venules in the mammalian microvasculature, gaps (ranging in size from 0. 1 to 1 mu m) have been reported within localized leaky sites. To investigate the quantitative relations between localized increases in permeability and changes in junction geometry, apparent solute permeability coefficients, in short segments of individually perfused microvessels in frog and hamster mesentery and hamster cheek pouch were measured at a series of capillary pressures in each vessel.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
EditorsA.G. Erdman
Place of PublicationNew York, NY, USA
PublisherASME (DE v 12)
Pages157
Number of pages1
Volume3
StatePublished - 1987

ASJC Scopus subject areas

  • Engineering(all)

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    Curry, F. R. E., & Joyner, W. L. (1987). REGULATION OF ENDOTHELIAL PERMEABILITY IN SINGLE PERFUSED CAPILLARIES. In A. G. Erdman (Ed.), American Society of Mechanical Engineers, Bioengineering Division (Publication) BED (Vol. 3, pp. 157). ASME (DE v 12).