Regulation of dendritic branching by Cdc42 GAPs

Sergi Simo Olivar, Jonathan A. Cooper

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Nerve cells form elaborate, highly branched dendritic trees that are optimized for the receipt of synaptic signals. Recent work published in this issue of Genes & Development by Rosario and colleagues (pp. 1743-1757) shows that a Cdc42-specific GTPase-activating protein (NOMA-GAP) regulates the branching of dendrites by neurons in the top layers of the mouse cortex. The results raise interesting questions regarding the specification of arbors in different cortical layers and the mechanisms of dendrite branching.

Original languageEnglish (US)
Pages (from-to)1653-1658
Number of pages6
JournalGenes and Development
Volume26
Issue number15
DOIs
StatePublished - Aug 1 2012
Externally publishedYes

Fingerprint

Dendrites
GTPase-Activating Proteins
Neurons
Genes

Keywords

  • Cdc42
  • Cofilin
  • Dendritic branching
  • Dendritic complexity
  • Neocortical development
  • Neuronal differentiation
  • NOMA-GAP

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Regulation of dendritic branching by Cdc42 GAPs. / Simo Olivar, Sergi; Cooper, Jonathan A.

In: Genes and Development, Vol. 26, No. 15, 01.08.2012, p. 1653-1658.

Research output: Contribution to journalArticle

Simo Olivar, Sergi ; Cooper, Jonathan A. / Regulation of dendritic branching by Cdc42 GAPs. In: Genes and Development. 2012 ; Vol. 26, No. 15. pp. 1653-1658.
@article{fe1e79163c6847eea03e30d1d7d85330,
title = "Regulation of dendritic branching by Cdc42 GAPs",
abstract = "Nerve cells form elaborate, highly branched dendritic trees that are optimized for the receipt of synaptic signals. Recent work published in this issue of Genes & Development by Rosario and colleagues (pp. 1743-1757) shows that a Cdc42-specific GTPase-activating protein (NOMA-GAP) regulates the branching of dendrites by neurons in the top layers of the mouse cortex. The results raise interesting questions regarding the specification of arbors in different cortical layers and the mechanisms of dendrite branching.",
keywords = "Cdc42, Cofilin, Dendritic branching, Dendritic complexity, Neocortical development, Neuronal differentiation, NOMA-GAP",
author = "{Simo Olivar}, Sergi and Cooper, {Jonathan A.}",
year = "2012",
month = "8",
day = "1",
doi = "10.1101/gad.199034.112",
language = "English (US)",
volume = "26",
pages = "1653--1658",
journal = "Genes and Development",
issn = "0890-9369",
publisher = "Cold Spring Harbor Laboratory Press",
number = "15",

}

TY - JOUR

T1 - Regulation of dendritic branching by Cdc42 GAPs

AU - Simo Olivar, Sergi

AU - Cooper, Jonathan A.

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Nerve cells form elaborate, highly branched dendritic trees that are optimized for the receipt of synaptic signals. Recent work published in this issue of Genes & Development by Rosario and colleagues (pp. 1743-1757) shows that a Cdc42-specific GTPase-activating protein (NOMA-GAP) regulates the branching of dendrites by neurons in the top layers of the mouse cortex. The results raise interesting questions regarding the specification of arbors in different cortical layers and the mechanisms of dendrite branching.

AB - Nerve cells form elaborate, highly branched dendritic trees that are optimized for the receipt of synaptic signals. Recent work published in this issue of Genes & Development by Rosario and colleagues (pp. 1743-1757) shows that a Cdc42-specific GTPase-activating protein (NOMA-GAP) regulates the branching of dendrites by neurons in the top layers of the mouse cortex. The results raise interesting questions regarding the specification of arbors in different cortical layers and the mechanisms of dendrite branching.

KW - Cdc42

KW - Cofilin

KW - Dendritic branching

KW - Dendritic complexity

KW - Neocortical development

KW - Neuronal differentiation

KW - NOMA-GAP

UR - http://www.scopus.com/inward/record.url?scp=84864742983&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864742983&partnerID=8YFLogxK

U2 - 10.1101/gad.199034.112

DO - 10.1101/gad.199034.112

M3 - Article

C2 - 22855828

AN - SCOPUS:84864742983

VL - 26

SP - 1653

EP - 1658

JO - Genes and Development

JF - Genes and Development

SN - 0890-9369

IS - 15

ER -