Regulation of dendritic branching by Cdc42 GAPs

Sergi Simo Olivar, Jonathan A. Cooper

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Nerve cells form elaborate, highly branched dendritic trees that are optimized for the receipt of synaptic signals. Recent work published in this issue of Genes & Development by Rosario and colleagues (pp. 1743-1757) shows that a Cdc42-specific GTPase-activating protein (NOMA-GAP) regulates the branching of dendrites by neurons in the top layers of the mouse cortex. The results raise interesting questions regarding the specification of arbors in different cortical layers and the mechanisms of dendrite branching.

Original languageEnglish (US)
Pages (from-to)1653-1658
Number of pages6
JournalGenes and Development
Volume26
Issue number15
DOIs
StatePublished - Aug 1 2012
Externally publishedYes

Keywords

  • Cdc42
  • Cofilin
  • Dendritic branching
  • Dendritic complexity
  • Neocortical development
  • Neuronal differentiation
  • NOMA-GAP

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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