Regulation of cytoplasmic dynein motility

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cytoplasmic dynein is responsible for a diverse range of intracellular movements. Dynein is the largest and the most complex of the known microtubule motor proteins. Its mechanochemical mechanism is subject to diverse allosteric inputs that change the motor's output and presumably adapt it for specific intracellular tasks. One of these allosteric regulators is the 23-subunit dynactin complex. There is evidence for the role of dynactin in dynein motility in nearly every cellular context in which dynein has been studied, yet the molecular mechanism for dynactin function remains elusive. Recently, several large leaps in parsing both the structure and function of dynactin have been made by several groups. This chapter will detail an updated understanding of the role of dynactin in dynein motility.

Original languageEnglish (US)
Title of host publicationDyneins
Subtitle of host publicationThe Biology of Dynein Motors: Second Edition
PublisherElsevier Inc.
Pages451-469
Number of pages19
ISBN (Electronic)9780128097021
ISBN (Print)9780128094716
DOIs
StatePublished - Nov 22 2017

Keywords

  • BicD2
  • Cargo adaptor
  • DDB
  • Dynactin
  • Dynein
  • Microtubule
  • Tyrosination

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Mckenney, R. (2017). Regulation of cytoplasmic dynein motility. In Dyneins: The Biology of Dynein Motors: Second Edition (pp. 451-469). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-809471-6.00015-2