Regulation of cytokine-induced neutrophil chemoattractant in rat bone marrow-derived macrophages by inflammatory mediators

Tawni L. Crippen, Kirk C. Klasing, Dallas M. Hyde

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

During the course of inflammation, macrophages are highly influenced by their local environment and changes in the cytokine milieu. Exposure of macrophages to various factors during different phases of the inflammatory response may have a strong influence on the pattern of gene expression, which a macrophage exhibits. We examined how these mediators affect the regulation of the expression and production of cytokine-induced neutrophil chemoattractant (CINC). Our study demonstrates that CINC can be induced in bone marrow-derived macrophages by lipopolysaccharide, interleukin-1β, tumor necrosis factor-α (TNFα), and interferon-γ/TNFα. These mediators are factors which a macrophage would be expected to encounter early in an inflammatory process. In contrast, transforming growth factor-β (TGFβ), which is expressed late in the inflammatory process during mesenchymal cell proliferation and tissue repair, did not induce detectable amounts of CINC and functioned to suppress CINC production stimulated by early inflammatory mediators. Suppression of CINC production occurred whether TGFβ was added simultaneously, 12 or 24 h prior to the stimulus.

Original languageEnglish (US)
Pages (from-to)293-301
Number of pages9
JournalPathobiology
Volume66
Issue number6
DOIs
StatePublished - 1998

Keywords

  • Bone marrow macrophage
  • Chemokine
  • Cytokine-induced neutrophil chemoattractant
  • Rat
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Biochemistry
  • Immunology and Allergy
  • Cell Biology

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