Abstract
We have reviewed the literature regarding the effects of fatty acids and their metabolites on cellular differentiation and apoptosis. Results obtained in different studies have been variable, but some generalizations can be made. Differentiation was increased by incubation of cells with arachidonic acid (AA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), prostaglandin E1 (PGE1), prostaglandin E2 (PGE2), or leukotriene D4 (LTD4). Effects of these agents on differentiation could be magnified with the simultaneous addition of other differentiation-inducing agents like dimethylsulfoxide or retinoic acid. AA and gamma-linolenic acid increased apoptosis while the effects of n-3 fatty acids (EPA and DHA) and of eicosanoids varied from stimulation to inhibition. These inconsistencies are attributed to the differences in methods used to evaluate differentiation and apoptosis, concentrations of fatty acids and serum, exposure time and the cell models used. Studies using the physiological concentrations of the fatty acids and standardized experimental conditions need to be conducted to establish effects of fatty acids and their metabolites on these cellular processes. Published by Elsevier Science Inc.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 381-393 |
| Number of pages | 13 |
| Journal | Nutrition Research |
| Volume | 21 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - 2001 |
Fingerprint
Keywords
- Apoptosis
- Differentiation
- Leukotrienes
- Long chain fatty acids
- Prostaglandins
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Regulation of cellular differentiation and apoptosis by fatty acids and their metabolites. / Rudolph, I. L.; Kelley, D. S.; Klasing, K. C.; Erickson, Kent L.
In: Nutrition Research, Vol. 21, No. 1-2, 2001, p. 381-393.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of cellular differentiation and apoptosis by fatty acids and their metabolites
AU - Rudolph, I. L.
AU - Kelley, D. S.
AU - Klasing, K. C.
AU - Erickson, Kent L
PY - 2001
Y1 - 2001
N2 - We have reviewed the literature regarding the effects of fatty acids and their metabolites on cellular differentiation and apoptosis. Results obtained in different studies have been variable, but some generalizations can be made. Differentiation was increased by incubation of cells with arachidonic acid (AA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), prostaglandin E1 (PGE1), prostaglandin E2 (PGE2), or leukotriene D4 (LTD4). Effects of these agents on differentiation could be magnified with the simultaneous addition of other differentiation-inducing agents like dimethylsulfoxide or retinoic acid. AA and gamma-linolenic acid increased apoptosis while the effects of n-3 fatty acids (EPA and DHA) and of eicosanoids varied from stimulation to inhibition. These inconsistencies are attributed to the differences in methods used to evaluate differentiation and apoptosis, concentrations of fatty acids and serum, exposure time and the cell models used. Studies using the physiological concentrations of the fatty acids and standardized experimental conditions need to be conducted to establish effects of fatty acids and their metabolites on these cellular processes. Published by Elsevier Science Inc.
AB - We have reviewed the literature regarding the effects of fatty acids and their metabolites on cellular differentiation and apoptosis. Results obtained in different studies have been variable, but some generalizations can be made. Differentiation was increased by incubation of cells with arachidonic acid (AA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), prostaglandin E1 (PGE1), prostaglandin E2 (PGE2), or leukotriene D4 (LTD4). Effects of these agents on differentiation could be magnified with the simultaneous addition of other differentiation-inducing agents like dimethylsulfoxide or retinoic acid. AA and gamma-linolenic acid increased apoptosis while the effects of n-3 fatty acids (EPA and DHA) and of eicosanoids varied from stimulation to inhibition. These inconsistencies are attributed to the differences in methods used to evaluate differentiation and apoptosis, concentrations of fatty acids and serum, exposure time and the cell models used. Studies using the physiological concentrations of the fatty acids and standardized experimental conditions need to be conducted to establish effects of fatty acids and their metabolites on these cellular processes. Published by Elsevier Science Inc.
KW - Apoptosis
KW - Differentiation
KW - Leukotrienes
KW - Long chain fatty acids
KW - Prostaglandins
UR - http://www.scopus.com/inward/record.url?scp=0035107164&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035107164&partnerID=8YFLogxK
U2 - 10.1016/S0271-5317(00)00285-2
DO - 10.1016/S0271-5317(00)00285-2
M3 - Article
C2 - 12749359
AN - SCOPUS:0035107164
VL - 21
SP - 381
EP - 393
JO - Nutrition Research
JF - Nutrition Research
SN - 0271-5317
IS - 1-2
ER -