Abstract
Quantum advances have recently been made in the understanding of the regulation of cartilage and bone differentiation through the identification, purification, genetic cloning and expression of recombinant bone morphogenetic proteins. Bone morphogenetic proteins are a family of pleiotropic differentiation factors with actions on chemotaxis, mitosis, initiation and promotion of chondrogenic and osteogenic phenotypes. They bind extracellular matrix components, heparin and type IV collagen and initiate bone repair. The cascade of cartilage and bone differentiation consists of several continuous phases: initiation, promotion, maintenance and termination.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 850-855 |
| Number of pages | 6 |
| Journal | Current Opinion in Cell Biology |
| Volume | 4 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cell Biology
Cite this
Regulation of cartilage and bone differentiation by bone morphogenetic proteins. / Reddi, A Hari.
In: Current Opinion in Cell Biology, Vol. 4, No. 5, 1992, p. 850-855.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of cartilage and bone differentiation by bone morphogenetic proteins
AU - Reddi, A Hari
PY - 1992
Y1 - 1992
N2 - Quantum advances have recently been made in the understanding of the regulation of cartilage and bone differentiation through the identification, purification, genetic cloning and expression of recombinant bone morphogenetic proteins. Bone morphogenetic proteins are a family of pleiotropic differentiation factors with actions on chemotaxis, mitosis, initiation and promotion of chondrogenic and osteogenic phenotypes. They bind extracellular matrix components, heparin and type IV collagen and initiate bone repair. The cascade of cartilage and bone differentiation consists of several continuous phases: initiation, promotion, maintenance and termination.
AB - Quantum advances have recently been made in the understanding of the regulation of cartilage and bone differentiation through the identification, purification, genetic cloning and expression of recombinant bone morphogenetic proteins. Bone morphogenetic proteins are a family of pleiotropic differentiation factors with actions on chemotaxis, mitosis, initiation and promotion of chondrogenic and osteogenic phenotypes. They bind extracellular matrix components, heparin and type IV collagen and initiate bone repair. The cascade of cartilage and bone differentiation consists of several continuous phases: initiation, promotion, maintenance and termination.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026453628&partnerID=8YFLogxK
U2 - 10.1016/0955-0674(92)90110-X
DO - 10.1016/0955-0674(92)90110-X
M3 - Article
VL - 4
SP - 850
EP - 855
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
IS - 5
ER -