Regulation of cartilage and bone differentiation by bone morphogenetic proteins

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Quantum advances have recently been made in the understanding of the regulation of cartilage and bone differentiation through the identification, purification, genetic cloning and expression of recombinant bone morphogenetic proteins. Bone morphogenetic proteins are a family of pleiotropic differentiation factors with actions on chemotaxis, mitosis, initiation and promotion of chondrogenic and osteogenic phenotypes. They bind extracellular matrix components, heparin and type IV collagen and initiate bone repair. The cascade of cartilage and bone differentiation consists of several continuous phases: initiation, promotion, maintenance and termination.

Original languageEnglish (US)
Pages (from-to)850-855
Number of pages6
JournalCurrent Opinion in Cell Biology
Issue number5
StatePublished - 1992
Externally publishedYes


ASJC Scopus subject areas

  • Cell Biology

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