Regulation of cartilage and bone differentiation by bone morphogenetic proteins

Research output: Contribution to journalArticle

231 Citations (Scopus)

Abstract

Quantum advances have recently been made in the understanding of the regulation of cartilage and bone differentiation through the identification, purification, genetic cloning and expression of recombinant bone morphogenetic proteins. Bone morphogenetic proteins are a family of pleiotropic differentiation factors with actions on chemotaxis, mitosis, initiation and promotion of chondrogenic and osteogenic phenotypes. They bind extracellular matrix components, heparin and type IV collagen and initiate bone repair. The cascade of cartilage and bone differentiation consists of several continuous phases: initiation, promotion, maintenance and termination.

Original languageEnglish (US)
Pages (from-to)850-855
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume4
Issue number5
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Bone Morphogenetic Proteins
Cartilage
Bone and Bones
Collagen Type IV
Chemotaxis
Recombinant Proteins
Mitosis
Extracellular Matrix
Heparin
Organism Cloning
Maintenance
Phenotype

ASJC Scopus subject areas

  • Cell Biology

Cite this

Regulation of cartilage and bone differentiation by bone morphogenetic proteins. / Reddi, A Hari.

In: Current Opinion in Cell Biology, Vol. 4, No. 5, 1992, p. 850-855.

Research output: Contribution to journalArticle

@article{af0302616e3e464187ac12768a8f0d78,
title = "Regulation of cartilage and bone differentiation by bone morphogenetic proteins",
abstract = "Quantum advances have recently been made in the understanding of the regulation of cartilage and bone differentiation through the identification, purification, genetic cloning and expression of recombinant bone morphogenetic proteins. Bone morphogenetic proteins are a family of pleiotropic differentiation factors with actions on chemotaxis, mitosis, initiation and promotion of chondrogenic and osteogenic phenotypes. They bind extracellular matrix components, heparin and type IV collagen and initiate bone repair. The cascade of cartilage and bone differentiation consists of several continuous phases: initiation, promotion, maintenance and termination.",
author = "Reddi, {A Hari}",
year = "1992",
doi = "10.1016/0955-0674(92)90110-X",
language = "English (US)",
volume = "4",
pages = "850--855",
journal = "Current Opinion in Cell Biology",
issn = "0955-0674",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Regulation of cartilage and bone differentiation by bone morphogenetic proteins

AU - Reddi, A Hari

PY - 1992

Y1 - 1992

N2 - Quantum advances have recently been made in the understanding of the regulation of cartilage and bone differentiation through the identification, purification, genetic cloning and expression of recombinant bone morphogenetic proteins. Bone morphogenetic proteins are a family of pleiotropic differentiation factors with actions on chemotaxis, mitosis, initiation and promotion of chondrogenic and osteogenic phenotypes. They bind extracellular matrix components, heparin and type IV collagen and initiate bone repair. The cascade of cartilage and bone differentiation consists of several continuous phases: initiation, promotion, maintenance and termination.

AB - Quantum advances have recently been made in the understanding of the regulation of cartilage and bone differentiation through the identification, purification, genetic cloning and expression of recombinant bone morphogenetic proteins. Bone morphogenetic proteins are a family of pleiotropic differentiation factors with actions on chemotaxis, mitosis, initiation and promotion of chondrogenic and osteogenic phenotypes. They bind extracellular matrix components, heparin and type IV collagen and initiate bone repair. The cascade of cartilage and bone differentiation consists of several continuous phases: initiation, promotion, maintenance and termination.

UR - http://www.scopus.com/inward/record.url?scp=0026453628&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026453628&partnerID=8YFLogxK

U2 - 10.1016/0955-0674(92)90110-X

DO - 10.1016/0955-0674(92)90110-X

M3 - Article

VL - 4

SP - 850

EP - 855

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

SN - 0955-0674

IS - 5

ER -