Regulation of bile acid receptor activity

Yu Jui Yvonne Wan, Lili Sheng

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Many receptors can be activated by bile acids (BAs) and their derivatives. These include nuclear receptors farnesoid X receptor (FXR), pregnane X receptor (PXR), and vitamin D receptor (VDR), as well as membrane receptors Takeda G protein receptor 5 (TGR5), sphingosine-1-phosphate receptor 2 (S1PR2), and cholinergic receptor muscarinic 2 (CHRM2). All of them are implicated in the development of metabolic and immunological diseases in response to endobiotic and xenobiotic exposure. Because epigenetic regulation is critical for organisms to adapt to constant environmental changes, this review article summarizes epigenetic regulation as well as post-transcriptional modification of bile acid receptors. In addition, the focus of this review is on the liver and digestive tract although these receptors may have effects on other organs. Those regulatory mechanisms are implicated in the disease process and critically important in uncovering innovative strategy for prevention and treatment of metabolic and immunological diseases.

Original languageEnglish (US)
Pages (from-to)180-185
Number of pages6
JournalLiver Research
Volume2
Issue number4
DOIs
StatePublished - Dec 2018

Fingerprint

Metabolic Diseases
Immune System Diseases
Bile Acids and Salts
Epigenomics
Lysosphingolipid Receptors
Calcitriol Receptors
Cholinergic Receptors
Xenobiotics
Cytoplasmic and Nuclear Receptors
GTP-Binding Proteins
Cholinergic Agents
Gastrointestinal Tract
Membranes
Liver
pregnane X receptor

Keywords

  • Acetylation
  • Bile acid receptor
  • Farnesoid X receptor (FXR)
  • G protein-coupled bile acid receptor
  • Glycosylation
  • Methylation
  • Sphingosine-1-phosphate receptor 2 (S1PR2)
  • Takeda G protein receptor 5 (TGR5)

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Regulation of bile acid receptor activity. / Wan, Yu Jui Yvonne; Sheng, Lili.

In: Liver Research, Vol. 2, No. 4, 12.2018, p. 180-185.

Research output: Contribution to journalReview article

Wan, Yu Jui Yvonne ; Sheng, Lili. / Regulation of bile acid receptor activity. In: Liver Research. 2018 ; Vol. 2, No. 4. pp. 180-185.
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