Regulation of airway innate and adaptive immune responses: The IL-17 paradigm

Li Yin Hung, Sharlene Velichko, Fei Huang, Philip Thai, Reen Wu

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

IL-17 is a proinflammatory cytokine produced by immune cells. Its significance in host defense and disease development has been demonstrated in various infection and autoimmune models. Recently, additional studies have shown that IL-17 is also important in modulating airway immune response in several aspects. Along with the well-established Th1/Th2 model, new discoveries regarding the Th17 lineage and IL-17 functions have added an extra twist to the already complicated cytokine network that regulates airway immunity. The IL-17 receptor is expressed on blood cells, as well as on structural cells such as the epithelial cells in the airway. Therefore, the effect of IL-17 on airway immunity is very broad, covering both the innate and the adaptive aspects. In this review, we summarize the findings of recent studies on IL-17 signaling and function in pulmonary immune response, and the implications of IL-17 in disease pathogenesis.

Original languageEnglish (US)
Pages (from-to)269-279
Number of pages11
JournalCritical Reviews in Immunology
Volume28
Issue number4
StatePublished - 2008

Keywords

  • Airway
  • Cytokine
  • Epithelial cells
  • IL-17
  • Immunity

ASJC Scopus subject areas

  • Immunology

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