Regression of oxymetholone-induced hepatic tumors after bone marrow transplantation in aplastic anemia

R. R. Montgomery, Jonathan M Ducore, J. H. Githens, C. S. August, M. L. Johnson

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Treatment of acquired aplastic anemia with androgens has been occasionally associated with the development of hepatic tumors. We have studied a 13-year-old boy with idiopathic aplastic anemia in whom oxymetholone treatment was associated with a partial hematological remission. Thirty-four months later, however, the patient developed multiple hepatic tumors. When oxymetholone therapy was discontinued, the aplastic anemia relapsed. He then underwent bone marrow transplantation from his HLA-A, B, and D-compatible sibling. This was followed by hematological and immunological reconstitution. The hepatic tumors underwent progressive regression after bone marrow transplantation. The patient is now 3 years post-bone marrow transplantation and is in complete remission of his aplastic anemia with no evidence of detectable liver tumors.

Original languageEnglish (US)
Pages (from-to)90-96
Number of pages7
JournalTransplantation
Volume30
Issue number2
StatePublished - 1980
Externally publishedYes

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Oxymetholone
Aplastic Anemia
Bone Marrow Transplantation
Liver
Neoplasms
HLA-D Antigens
HLA-A Antigens
HLA-B Antigens
Androgens
Siblings
Therapeutics

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Montgomery, R. R., Ducore, J. M., Githens, J. H., August, C. S., & Johnson, M. L. (1980). Regression of oxymetholone-induced hepatic tumors after bone marrow transplantation in aplastic anemia. Transplantation, 30(2), 90-96.

Regression of oxymetholone-induced hepatic tumors after bone marrow transplantation in aplastic anemia. / Montgomery, R. R.; Ducore, Jonathan M; Githens, J. H.; August, C. S.; Johnson, M. L.

In: Transplantation, Vol. 30, No. 2, 1980, p. 90-96.

Research output: Contribution to journalArticle

Montgomery, RR, Ducore, JM, Githens, JH, August, CS & Johnson, ML 1980, 'Regression of oxymetholone-induced hepatic tumors after bone marrow transplantation in aplastic anemia', Transplantation, vol. 30, no. 2, pp. 90-96.
Montgomery, R. R. ; Ducore, Jonathan M ; Githens, J. H. ; August, C. S. ; Johnson, M. L. / Regression of oxymetholone-induced hepatic tumors after bone marrow transplantation in aplastic anemia. In: Transplantation. 1980 ; Vol. 30, No. 2. pp. 90-96.
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